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@ARTICLE{Neuner:10458,
      author       = {Neuner, I. and Stöcker, T. and Kellermann, T. and Ermer,
                      V. and Wegener, H.P. and Eickhoff, S. B. and Schneider, F.
                      and Shah, J. N.},
      title        = {{E}lectrophysiology meets f{MRI}: {N}eural correlates of
                      the startle reflex assessed by simultaneous {EMG}-f{MRI}
                      data acquisition},
      journal      = {Human brain mapping},
      volume       = {31},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-10458},
      pages        = {1675 - 1685},
      year         = {2010},
      note         = {Contract grant sponsor Bundesministerium fur Bildung und
                      Forschung (BMBF), Contract grant numbers. BMBF 01GO0104 (to
                      N.J S and Karl Zilles), BMBF 01GO0204 (to Brain Imaging
                      Centre West); Contract grant sponsors Medical Faculty of the
                      RWTH Aachen University ("Rotationsprogramm"; to IN)},
      abstract     = {The startle reflex provides a unique tool for the
                      investigation of sensorimotor gating and information
                      processing. Simultaneous EMG-fMRI acquisition (i.e., online
                      stimulation and recording in the MR environment) allows for
                      the quantitative assessment of the neuronal correlates of
                      the startle reflex and its modulations on a single trial
                      level. This serves as the backbone for a startle response
                      informed fMRI analysis, which is fed by data acquired in the
                      same brain at the same time. We here present the first MR
                      study using a single trial approach with simultaneous
                      acquired EMG and fMRI data on the human startle response in
                      15 healthy young men. It investigates the neural correlates
                      for isolated air puff startle pulses (PA), prepulse-pulse
                      inhibition (PPI), and prepulse facilitation (PPF). We
                      identified a common core network engaged by all three
                      conditions (PA, PPI, and PPF), consisting of bilateral
                      primary and secondary somatosensory cortices, right insula,
                      right thalamus, right temporal pole, middle cingulate
                      cortex, and cerebellum. The cerebellar vermis exhibits
                      distinct activation patterns between the startle
                      modifications. It is differentially activated with the
                      highest amplitude for PPF, a lower activation for PA, and
                      lowest for PPI. The orbital frontal cortex exhibits a
                      differential activation pattern, not for the type of startle
                      response but for the amplitude modification. For pulse alone
                      it is close to zero; for PPI it is activated. This is in
                      contrast to PPF where it shows deactivation. In addition,
                      the thalamus, the cerebellum, and the anterior cingulate
                      cortex add to the modulation of the startle reflex.},
      keywords     = {Adult / Brain: physiology / Brain Mapping /
                      Electromyography: methods / Humans / Image Processing,
                      Computer-Assisted / Magnetic Resonance Imaging: methods /
                      Male / Physical Stimulation / Startle Reaction: physiology /
                      J (WoSType)},
      cin          = {INM-2 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89573 - Neuroimaging (POF2-89573)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89573},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20205248},
      UT           = {WOS:000283641100005},
      doi          = {10.1002/hbm.20965},
      url          = {https://juser.fz-juelich.de/record/10458},
}