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000010460 0247_ $$2DOI$$a10.1152/jn.00261.2010
000010460 0247_ $$2WOS$$aWOS:000281910600026
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000010460 041__ $$aeng
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000010460 084__ $$2WoS$$aNeurosciences
000010460 084__ $$2WoS$$aPhysiology
000010460 1001_ $$0P:(DE-Juel1)131855$$aCieslik, E.C.$$b0$$uFZJ
000010460 245__ $$aDissociating bottom-up and top-down processes in a manual stimulus-response compatibility task
000010460 260__ $$aBethesda, Md.$$bSoc.$$c2010
000010460 300__ $$a1472 - 1483
000010460 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010460 3367_ $$00$$2EndNote$$aJournal Article
000010460 3367_ $$2BibTeX$$aARTICLE
000010460 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000010460 3367_ $$2DRIVER$$aarticle
000010460 440_0 $$03600$$aJournal of Neurophysiology$$v104$$x0022-3077
000010460 500__ $$aThis work was supported by a grant from the Human Brain Project/Neuroinformatics Research (National Institute of Biomedical Imaging and Bioengineering, National Institute of Neurological Disorders and Stroke, National Institute of Mental Health [NIMH]) to K. Zilles; Human Brain Project/NIMH Grant R01-MH-074457-01A1 to S. B. Eickhoff; and a grant from the Helmholtz Initiative on Systems Biology to K. Zilles, S. B. Eickhoff, and E. C. Cieslik.
000010460 520__ $$aSpeed and accuracy of motor responses to lateralized stimuli are influenced by the spatial overlap between stimulus location and required response. Responses showing high spatial overlap with peripheral cues benefit from a bottom-up driven enhancement of attention to the respective location, whereas low overlap requires top-down modulated reorienting of resources. Here we investigated the interaction between these two processes using a spatial stimulus-response compatibility task. Subjects had to react to lateralized visual stimuli with a button press using either the ipsilateral (congruent condition) or the contralateral (incongruent condition) index finger. Stimulus-driven bottom-up processes were associated with significant contralateral activation in V5, the intraparietal sulcus (IPS) and the premotor cortex (PMC). Incongruent versus congruent responses evoked significant activation in bilateral IPS and PMC, highly overlapping with the activations found for stimulus-driven bottom-up processes, as well as additional activation in bilateral anterior insula and right dorsolateral prefrontal cortex (DLPFC) and temporoparietal junction (TPJ). Moreover, a region anterior to the bottom-up driven activation in the IPS was associated with top-down modulated directionality-specific reorienting of motor attention during incongruent motor responses. Based on these results, we propose that stimulus-driven activation of contralateral IPS and PMC represent key neuronal substrates for the behavioral advantage observed when reacting toward a congruently lateralized stimulus. Additional activation in bilateral insula and right DLPFC and TPJ during incongruent responses should reflect top-down control mechanisms mediating contextual (i.e., task) demands. Furthermore, this study provides evidence for both overlapping and disparate substrates of bottom-up and top-down modulated attentional processes in the IPS.
000010460 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
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000010460 588__ $$aDataset connected to Web of Science, Pubmed
000010460 650_2 $$2MeSH$$aAdult
000010460 650_2 $$2MeSH$$aAttention: physiology
000010460 650_2 $$2MeSH$$aBrain: physiology
000010460 650_2 $$2MeSH$$aFemale
000010460 650_2 $$2MeSH$$aHumans
000010460 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000010460 650_2 $$2MeSH$$aMale
000010460 650_2 $$2MeSH$$aMiddle Aged
000010460 650_2 $$2MeSH$$aPhotic Stimulation: methods
000010460 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000010460 650_2 $$2MeSH$$aReaction Time: physiology
000010460 650_2 $$2MeSH$$aYoung Adult
000010460 650_7 $$2WoSType$$aJ
000010460 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b1$$uFZJ
000010460 7001_ $$0P:(DE-Juel1)VDB67936$$aKurth, F.$$b2$$uFZJ
000010460 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b3$$uFZJ
000010460 773__ $$0PERI:(DE-600)1467889-5$$a10.1152/jn.00261.2010$$gVol. 104, p. 1472 - 1483$$p1472 - 1483$$q104<1472 - 1483$$tJournal of neurophysiology$$v104$$x0022-3077$$y2010
000010460 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944686
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000010460 915__ $$0StatID:(DE-HGF)0010$$aJCR/ISI refereed
000010460 9141_ $$y2010
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