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@ARTICLE{Cieslik:10460,
      author       = {Cieslik, E.C. and Zilles, K. and Kurth, F. and Eickhoff, S.
                      B.},
      title        = {{D}issociating bottom-up and top-down processes in a manual
                      stimulus-response compatibility task},
      journal      = {Journal of neurophysiology},
      volume       = {104},
      issn         = {0022-3077},
      address      = {Bethesda, Md.},
      publisher    = {Soc.},
      reportid     = {PreJuSER-10460},
      pages        = {1472 - 1483},
      year         = {2010},
      note         = {This work was supported by a grant from the Human Brain
                      Project/Neuroinformatics Research (National Institute of
                      Biomedical Imaging and Bioengineering, National Institute of
                      Neurological Disorders and Stroke, National Institute of
                      Mental Health [NIMH]) to K. Zilles; Human Brain Project/NIMH
                      Grant R01-MH-074457-01A1 to S. B. Eickhoff; and a grant from
                      the Helmholtz Initiative on Systems Biology to K. Zilles, S.
                      B. Eickhoff, and E. C. Cieslik.},
      abstract     = {Speed and accuracy of motor responses to lateralized
                      stimuli are influenced by the spatial overlap between
                      stimulus location and required response. Responses showing
                      high spatial overlap with peripheral cues benefit from a
                      bottom-up driven enhancement of attention to the respective
                      location, whereas low overlap requires top-down modulated
                      reorienting of resources. Here we investigated the
                      interaction between these two processes using a spatial
                      stimulus-response compatibility task. Subjects had to react
                      to lateralized visual stimuli with a button press using
                      either the ipsilateral (congruent condition) or the
                      contralateral (incongruent condition) index finger.
                      Stimulus-driven bottom-up processes were associated with
                      significant contralateral activation in V5, the
                      intraparietal sulcus (IPS) and the premotor cortex (PMC).
                      Incongruent versus congruent responses evoked significant
                      activation in bilateral IPS and PMC, highly overlapping with
                      the activations found for stimulus-driven bottom-up
                      processes, as well as additional activation in bilateral
                      anterior insula and right dorsolateral prefrontal cortex
                      (DLPFC) and temporoparietal junction (TPJ). Moreover, a
                      region anterior to the bottom-up driven activation in the
                      IPS was associated with top-down modulated
                      directionality-specific reorienting of motor attention
                      during incongruent motor responses. Based on these results,
                      we propose that stimulus-driven activation of contralateral
                      IPS and PMC represent key neuronal substrates for the
                      behavioral advantage observed when reacting toward a
                      congruently lateralized stimulus. Additional activation in
                      bilateral insula and right DLPFC and TPJ during incongruent
                      responses should reflect top-down control mechanisms
                      mediating contextual (i.e., task) demands. Furthermore, this
                      study provides evidence for both overlapping and disparate
                      substrates of bottom-up and top-down modulated attentional
                      processes in the IPS.},
      keywords     = {Adult / Attention: physiology / Brain: physiology / Female
                      / Humans / Magnetic Resonance Imaging: methods / Male /
                      Middle Aged / Photic Stimulation: methods / Psychomotor
                      Performance: physiology / Reaction Time: physiology / Young
                      Adult / J (WoSType)},
      cin          = {INM-2 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Neurosciences / Physiology},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:20573974},
      pmc          = {pmc:PMC2944686},
      UT           = {WOS:000281910600026},
      doi          = {10.1152/jn.00261.2010},
      url          = {https://juser.fz-juelich.de/record/10460},
}