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000010461 0247_ $$2DOI$$a10.1016/j.neuroimage.2010.06.053
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000010461 084__ $$2WoS$$aNeurosciences
000010461 084__ $$2WoS$$aNeuroimaging
000010461 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000010461 1001_ $$0P:(DE-HGF)0$$aHunter, M.D.$$b0
000010461 245__ $$aThe state of tranquility: Subjective perception is shaped by contextual modulation of auditory connectivity
000010461 260__ $$aOrlando, Fla.$$bAcademic Press$$c2010
000010461 300__ $$a611 - 618
000010461 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010461 440_0 $$04545$$aNeuroImage$$v53$$x1053-8119$$y2
000010461 500__ $$aSBE acknowledges funding by the Human Brain Project (R01-MH074457-01A1), the DFG (IRTG 1328, SBE) and the Initiative and Networking Fund of the Helmholtz Association within the Helmholtz Alliance on Systems Biology (The Human Brain Model). The stimuli used in this work were recorded with support from the Engineering and Physical Sciences Research Council (Grant EP/P500095/1). We thank Mr M Brook for assistance with figure production and Mrs. J Woodhead for assistance with manuscript preparation The radiographic skills of the University of Sheffield's MRI Unit are gratefully acknowledged.
000010461 520__ $$aIn this study, we investigated brain mechanisms for the generation of subjective experience from objective sensory inputs. Our experimental construct was subjective tranquility. Tranquility is a mental state more likely to occur in the presence of objective sensory inputs that arise from natural features in the environment. We used functional magnetic resonance imaging to examine the neural response to scenes that were visually distinct (beach images vs. freeway images) and experienced as tranquil (beach) or non-tranquil (freeway). Both sets of scenes had the same auditory component because waves breaking on a beach and vehicles moving on a freeway can produce similar auditory spectral and temporal characteristics, perceived as a constant roar. Compared with scenes experienced as non-tranquil, we found that subjectively tranquil scenes were associated with significantly greater effective connectivity between the auditory cortex and medial prefrontal cortex, a region implicated in the evaluation of mental states. Similarly enhanced connectivity was also observed between the auditory cortex and posterior cingulate gyrus, temporoparietal cortex and thalamus. These findings demonstrate that visual context can modulate connectivity of the auditory cortex with regions implicated in the generation of subjective states. Importantly, this effect arises under conditions of identical auditory input. Hence, the same sound may be associated with different percepts reflecting varying connectivity between the auditory cortex and other brain regions. This suggests that subjective experience is more closely linked to the connectivity state of the auditory cortex than to its basic sensory inputs.
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000010461 588__ $$aDataset connected to Web of Science, Pubmed
000010461 650_2 $$2MeSH$$aAcoustic Stimulation
000010461 650_2 $$2MeSH$$aAffect: physiology
000010461 650_2 $$2MeSH$$aAuditory Cortex: physiology
000010461 650_2 $$2MeSH$$aBrain Mapping
000010461 650_2 $$2MeSH$$aEcho-Planar Imaging
000010461 650_2 $$2MeSH$$aEnvironment
000010461 650_2 $$2MeSH$$aFunctional Laterality: physiology
000010461 650_2 $$2MeSH$$aHumans
000010461 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000010461 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000010461 650_2 $$2MeSH$$aMale
000010461 650_2 $$2MeSH$$aNerve Net: physiology
000010461 650_2 $$2MeSH$$aNeural Pathways: physiology
000010461 650_2 $$2MeSH$$aOxygen: blood
000010461 650_2 $$2MeSH$$aPerception: physiology
000010461 650_2 $$2MeSH$$aPhotic Stimulation
000010461 650_2 $$2MeSH$$aPrefrontal Cortex: physiology
000010461 650_2 $$2MeSH$$aThalamus: physiology
000010461 650_2 $$2MeSH$$aYoung Adult
000010461 650_7 $$07782-44-7$$2NLM Chemicals$$aOxygen
000010461 650_7 $$2WoSType$$aJ
000010461 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, S. B.$$b1$$uFZJ
000010461 7001_ $$0P:(DE-HGF)0$$aPheasant, R.J.$$b2
000010461 7001_ $$0P:(DE-HGF)0$$aDouglas, M.J.$$b3
000010461 7001_ $$0P:(DE-HGF)0$$aWatts, G.R.$$b4
000010461 7001_ $$0P:(DE-Juel1)VDB93201$$aFarrow, T.F.D.$$b5$$uFZJ
000010461 7001_ $$0P:(DE-HGF)0$$aHyland, D.$$b6
000010461 7001_ $$0P:(DE-HGF)0$$aKang, J.$$b7
000010461 7001_ $$0P:(DE-HGF)0$$aWilkinson, I.D.$$b8
000010461 7001_ $$0P:(DE-HGF)0$$aHoroshenkov, K.V.$$b9
000010461 7001_ $$0P:(DE-HGF)0$$aWoodruff, P.W.R.$$b10
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