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@ARTICLE{Strodel:1046338,
      author       = {Strodel, Birgit},
      title        = {{C}hameleonic {N}ature of {A} β : {I}mplications for
                      {A}lzheimer's and {O}ther {A}myloid {D}iseases},
      journal      = {Bioessays},
      volume       = {47},
      number       = {9},
      issn         = {0265-9247},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2025-03773},
      pages        = {e70039},
      year         = {2025},
      abstract     = {The amyloid-β peptide (Aβ), implicated in Alzheimer's
                      disease, exhibits significant polymorphism. At the monomer
                      level, Aβ can adopt disordered, helical, and β-hairpin
                      structures, influenced by environmental conditions. Both
                      oligomeric and fibrillar states, characterized by the
                      prevalence of β-sheets, are polymorphic in the arrangement
                      of β-strands. This chameleon-like behavior arises from
                      Aβ’s unique sequence and relatively flat energy
                      landscape, which facilitates aggregation and may contribute
                      to the prevalence of Alzheimer's disease, while also
                      enabling disaggregation, thus slowing disease progression.
                      In contrast, Creutzfeldt-Jakob disease, which is much rarer,
                      progresses far more rapidly, likely due to the steeper
                      energy landscape of the prion protein.},
      cin          = {IBI-7},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5244 - Information Processing in Neuronal Networks
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5244},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {40641247},
      UT           = {WOS:001526776500001},
      doi          = {10.1002/bies.70039},
      url          = {https://juser.fz-juelich.de/record/1046338},
}