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@ARTICLE{Schmidt:1046821,
      author       = {Schmidt, Claudia C. and Bardakan, Michella M. and Jaeger,
                      Elena and Richter, Nils and Bischof, Gérard N. and Giehl,
                      Kathrin and Onur, Oezguer A. and Jessen, Frank and Fink,
                      Gereon R. and Drzezga, Alexander and Weiss-Blankenhorn,
                      Peter},
      title        = {{A}praxic deficits predict general cognitive impairment in
                      patients with biomarker-verified {A}lzheimer’s pathology},
      journal      = {Journal of neurology},
      volume       = {272},
      number       = {10},
      issn         = {0367-004X},
      address      = {[Darmstadt]},
      publisher    = {Steinkopff},
      reportid     = {FZJ-2025-03980},
      pages        = {654},
      year         = {2025},
      abstract     = {Apraxia represents a core feature of Alzheimer's disease
                      (AD), a neurodegenerative disorder characterised by the
                      accumulation of β-amyloid plaques and tau deposition.
                      However, systematic descriptions of apraxic deficits in AD
                      patients remain scarce. Here, we comprehensively investigate
                      apraxia profiles and their link with cognitive impairment in
                      patients with biomarker-verified Alzheimer's pathology. We
                      characterised the frequency and patterns of apraxic deficits
                      in patients with biomarker-verified Alzheimer's pathology
                      using a battery of standardised apraxia tests. Demographic
                      variables and apraxia scores were related to patients'
                      general cognitive impairment using hierarchical regression
                      analysis. Apraxic deficits were found in $67\%$ of patients
                      with biomarker-verified Alzheimer's pathology (n = 63).
                      Patients with Alzheimer's pathology were more impaired in
                      imitating finger gestures (than hand gestures: $89.2\%$ vs.
                      $80.0\%,$ p < 0.001) and imitating complex hand movements
                      (than single hand movements: $97.4\%$ vs. $78.5\%,$ p <
                      0.001), even when controlling for general cognitive
                      impairment. Apraxia assessments explained about $60\%$ of
                      the variance in dementia severity, with performance in the
                      KAS subtest of pantomiming object use (beta coefficient:
                      0.47, p = 0.001) and the DATE subtest for limb apraxia (beta
                      coefficient: 0.37, p = 0.005) constituting significant
                      predictors of general cognitive impairment. These findings
                      emphasise the relevance of apraxia in patients with
                      biomarker-verified Alzheimer's pathology, revealing that
                      praxis deficits predict general cognitive impairment in AD.
                      Further research is warranted into the role of apraxia as a
                      potential early diagnostic criterion in AD.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029) / DFG project
                      G:(GEPRIS)491111487 - Open-Access-Publikationskosten / 2025
                      - 2027 / Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029 /
                      G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1007/s00415-025-13401-9},
      url          = {https://juser.fz-juelich.de/record/1046821},
}