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000010471 0247_ $$2DOI$$a10.1016/j.neuroimage.2009.12.045
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000010471 084__ $$2WoS$$aNeurosciences
000010471 084__ $$2WoS$$aNeuroimaging
000010471 084__ $$2WoS$$aRadiology, Nuclear Medicine & Medical Imaging
000010471 1001_ $$0P:(DE-HGF)0$$aKochunov, P.$$b0
000010471 245__ $$aGenetics of primary cerebral gyrification: Heritability of length, depth and area of primary sulci in an extended pedigree of Papio baboons
000010471 260__ $$aOrlando, Fla.$$bAcademic Press$$c2010
000010471 300__ $$a1126 - 1134
000010471 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000010471 440_0 $$04545$$aNeuroImage$$v53$$x1053-8119$$y3
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000010471 520__ $$aGenetic control over morphological variability of primary sulci and gyri is of great interest in the evolutionary, developmental and clinical neurosciences. Primary structures emerge early in development and their morphology is thought to be related to neuronal differentiation, development of functional connections and cortical lateralization. We measured the proportional contributions of genetics and environment to regional variability, testing two theories regarding regional modulation of genetic influences by ontogenic and phenotypic factors. Our measures were surface area, and average length and depth of eleven primary cortical sulci from high-resolution MR images in 180 pedigreed baboons. Average heritability values for sulcal area, depth and length (h(2)(Area)=.38+/-.22; h(2)(Depth)=.42+/-.23; h(2)(Length)=.34+/-.22) indicated that regional cortical anatomy is under genetic control. The regional pattern of genetic contributions was complex and, contrary to previously proposed theories, did not depend upon sulcal depth, or upon the sequence in which structures appear during development. Our results imply that heritability of sulcal phenotypes may be regionally modulated by arcuate U-fiber systems. However, further research is necessary to unravel the complexity of genetic contributions to cortical morphology.
000010471 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000010471 536__ $$0G:(DE-HGF)POF2-89571$$a89571 - Connectivity and Activity (POF2-89571)$$cPOF2-89571$$fPOF II T$$x1
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000010471 650_2 $$2MeSH$$aAnimals
000010471 650_2 $$2MeSH$$aBrain: anatomy & histology
000010471 650_2 $$2MeSH$$aFemale
000010471 650_2 $$2MeSH$$aImage Processing, Computer-Assisted
000010471 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000010471 650_2 $$2MeSH$$aMale
000010471 650_2 $$2MeSH$$aPapio: anatomy & histology
000010471 650_2 $$2MeSH$$aPapio: genetics
000010471 650_2 $$2MeSH$$aQuantitative Trait, Heritable
000010471 650_7 $$2WoSType$$aJ
000010471 7001_ $$0P:(DE-HGF)0$$aGlahn, D.C.$$b1
000010471 7001_ $$0P:(DE-HGF)0$$aFox, P.T.$$b2
000010471 7001_ $$0P:(DE-HGF)0$$aLancaster, J.L.$$b3
000010471 7001_ $$0P:(DE-HGF)0$$aSaleem, K.$$b4
000010471 7001_ $$0P:(DE-HGF)0$$aShelledy, W.$$b5
000010471 7001_ $$0P:(DE-Juel1)131714$$aZilles, K.$$b6$$uFZJ
000010471 7001_ $$0P:(DE-HGF)0$$aThompson, P.M.$$b7
000010471 7001_ $$0P:(DE-HGF)0$$aCoulon, O.$$b8
000010471 7001_ $$0P:(DE-HGF)0$$aMangin, J.F.$$b9
000010471 7001_ $$0P:(DE-HGF)0$$aBlangero, J.$$b10
000010471 7001_ $$0P:(DE-HGF)0$$aRogers, J.$$b11
000010471 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2009.12.045$$gVol. 53, p. 1126 - 1134$$p1126 - 1134$$q53<1126 - 1134$$tNeuroImage$$v53$$x1053-8119$$y2010
000010471 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888833
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