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005     20210129210522.0
024 7 _ |2 pmid
|a pmid:20035879
024 7 _ |2 pmc
|a pmc:PMC2888833
024 7 _ |2 DOI
|a 10.1016/j.neuroimage.2009.12.045
024 7 _ |2 WOS
|a WOS:000282039300039
037 _ _ |a PreJuSER-10471
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Neurosciences
084 _ _ |2 WoS
|a Neuroimaging
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Kochunov, P.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Genetics of primary cerebral gyrification: Heritability of length, depth and area of primary sulci in an extended pedigree of Papio baboons
260 _ _ |a Orlando, Fla.
|b Academic Press
|c 2010
300 _ _ |a 1126 - 1134
336 7 _ |a Journal Article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
440 _ 0 |a NeuroImage
|x 1053-8119
|0 4545
|y 3
|v 53
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Genetic control over morphological variability of primary sulci and gyri is of great interest in the evolutionary, developmental and clinical neurosciences. Primary structures emerge early in development and their morphology is thought to be related to neuronal differentiation, development of functional connections and cortical lateralization. We measured the proportional contributions of genetics and environment to regional variability, testing two theories regarding regional modulation of genetic influences by ontogenic and phenotypic factors. Our measures were surface area, and average length and depth of eleven primary cortical sulci from high-resolution MR images in 180 pedigreed baboons. Average heritability values for sulcal area, depth and length (h(2)(Area)=.38+/-.22; h(2)(Depth)=.42+/-.23; h(2)(Length)=.34+/-.22) indicated that regional cortical anatomy is under genetic control. The regional pattern of genetic contributions was complex and, contrary to previously proposed theories, did not depend upon sulcal depth, or upon the sequence in which structures appear during development. Our results imply that heritability of sulcal phenotypes may be regionally modulated by arcuate U-fiber systems. However, further research is necessary to unravel the complexity of genetic contributions to cortical morphology.
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536 _ _ |a 89571 - Connectivity and Activity (POF2-89571)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Animals
650 _ 2 |2 MeSH
|a Brain: anatomy & histology
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Image Processing, Computer-Assisted
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging
650 _ 2 |2 MeSH
|a Male
650 _ 2 |2 MeSH
|a Papio: anatomy & histology
650 _ 2 |2 MeSH
|a Papio: genetics
650 _ 2 |2 MeSH
|a Quantitative Trait, Heritable
650 _ 7 |a J
|2 WoSType
700 1 _ |a Glahn, D.C.
|b 1
|0 P:(DE-HGF)0
700 1 _ |a Fox, P.T.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Lancaster, J.L.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Saleem, K.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Shelledy, W.
|b 5
|0 P:(DE-HGF)0
700 1 _ |a Zilles, K.
|b 6
|u FZJ
|0 P:(DE-Juel1)131714
700 1 _ |a Thompson, P.M.
|b 7
|0 P:(DE-HGF)0
700 1 _ |a Coulon, O.
|b 8
|0 P:(DE-HGF)0
700 1 _ |a Mangin, J.F.
|b 9
|0 P:(DE-HGF)0
700 1 _ |a Blangero, J.
|b 10
|0 P:(DE-HGF)0
700 1 _ |a Rogers, J.
|b 11
|0 P:(DE-HGF)0
773 _ _ |a 10.1016/j.neuroimage.2009.12.045
|g Vol. 53, p. 1126 - 1134
|p 1126 - 1134
|q 53<1126 - 1134
|0 PERI:(DE-600)1471418-8
|t NeuroImage
|v 53
|y 2010
|x 1053-8119
856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888833
909 C O |o oai:juser.fz-juelich.de:10471
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913 2 _ |a DE-HGF
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|l Decoding the Human Brain
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914 1 _ |y 2010
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980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)VDB1046


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