% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Grumbach:1047195,
      author       = {Grumbach, Pascal and Kasper, Jan and Hipp, Joerg F. and
                      Forsyth, Anna and Valk, Sofie L. and Muthukumaraswamy,
                      Suresh and Eickhoff, Simon B. and Schilbach, Leonhard and
                      Dukart, Juergen},
      title        = {{L}ocal activity alterations in individuals with autism
                      correlate with neurotransmitter properties and
                      ketamine-induced brain changes},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2025-04144},
      pages        = {8248},
      year         = {2025},
      abstract     = {Autism is a neurodevelopmental condition associated with
                      altered resting-state brain function. An increased
                      excitation-inhibition ratio is discussed as a pathomechanism
                      but in-vivo evidence of disturbed neurotransmission
                      underlying functional alterations remains scarce. We compare
                      local resting-state brain activity and neurotransmitter
                      co-localizations between autism (N = 405, N = 395) and
                      neurotypical controls (N = 473, N = 474) in two independent
                      cohorts and correlate them with excitation-inhibition
                      changes induced by glutamatergic (ketamine) and GABAergic
                      (midazolam) medication. Autistic individuals exhibit
                      consistent reductions in local activity, particularly in
                      default mode network regions. The whole-brain differences
                      spatially overlap with glutamatergic and GABAergic, as well
                      as dopaminergic and cholinergic neurotransmission.
                      Functional changes induced by NMDA-antagonist ketamine
                      resemble the spatial pattern observed in autism. Our
                      findings suggest that consistent local activity alterations
                      in autism reflect widespread disruptions in
                      neurotransmission and may be resembled by pharmacological
                      modulation of the excitation-inhibition balance. These
                      findings advance understanding of the neurophysiological
                      basis of autism. Trial registration number:
                      ACTRN12616000281493.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s41467-025-63857-6},
      url          = {https://juser.fz-juelich.de/record/1047195},
}