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@ARTICLE{Schmidt:1047475,
      author       = {Schmidt, Patrick and Lindemeyer, Johannes and Raut, Pranali
                      and Schütz, Markus and Saniternik, Sven and Jönsson,
                      Jannika and Endepols, Heike and Fischer, Thomas and Quaas,
                      Alexander and Schlößer, Hans Anton and Thelen, Martin and
                      Grüll, Holger},
      title        = {{M}ultiparametric {C}haracterization of the {DSL}-6{A}/{C}1
                      {P}ancreatic {C}ancer {M}odel in {R}ats},
      journal      = {Cancers},
      volume       = {16},
      number       = {8},
      issn         = {2072-6694},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {FZJ-2025-04326},
      pages        = {1535},
      year         = {2024},
      note         = {This research was supported by the German Federal Ministry
                      of Education and Research (BMBF), grant number 13GW0364D
                      (“MR-HIFU Pancreas”).},
      abstract     = {The DSL-6A/C1 murine pancreatic ductal adenocarcinoma
                      (PDAC) tumor model was established in Lewis rats and
                      characterized through a comprehensive multiparametric
                      analysis to compare it to other preclinical tumor models and
                      explore potential diagnostic and therapeutical targets.
                      DSL-6A/C1 tumors were histologically analyzed to elucidate
                      PDAC features. The tumor microenvironment was studied for
                      immune cell prevalence. Multiparametric MRI and PET imaging
                      were utilized to characterize tumors, and
                      68Ga-FAPI-46-targeting cancer-associated fibroblasts (CAFs),
                      were used to validate the histological findings. The
                      histology confirmed typical PDAC characteristics, such as
                      malformed pancreatic ductal malignant cells and CAFs.
                      Distinct immune landscapes were identified, revealing an
                      increased presence of CD8+ T cells and a decreased CD4+ T
                      cell fraction within the tumor microenvironment. PET imaging
                      with 68Ga-FAPI tracers exhibited strong tracer uptake in
                      tumor tissues. The MRI parameters indicated increasing
                      intralesional necrosis over time and elevated contrast media
                      uptake in vital tumor areas. We have demonstrated that the
                      DSL-6A/C1 tumor model, particularly due to its high
                      tumorigenicity, tumor size, and 68Ga-FAPI-46 sensitivity, is
                      a suitable alternative to established small animal models
                      for many forms of preclinical analyses and therapeutic
                      studies of PDAC.},
      cin          = {INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3390/cancers16081535},
      url          = {https://juser.fz-juelich.de/record/1047475},
}