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@ARTICLE{Michel:1048136,
      author       = {Michel, M. and Sudbrock, F. and Neumaier, B. and Eberhardt,
                      K. and Strub, E.},
      title        = {{C}omparison of standard and modified 99{M}o/99m{T}c
                      radionuclide generators},
      journal      = {Journal of radioanalytical and nuclear chemistry},
      volume       = {334},
      number       = {10},
      issn         = {0022-4081},
      address      = {Dordrecht [u.a.]},
      publisher    = {Springer Science + Business Media B.V.},
      reportid     = {FZJ-2025-04518},
      pages        = {7255 - 7263},
      year         = {2025},
      note         = {This work is part of the ‘99MoBest’ joint projectand
                      was funded by the Federal Ministry of Education and
                      Research(BMBF) under funding number 02NUK080A.},
      abstract     = {99mTc is the most widely used radionuclide in medical
                      diagnostics and typically obtained from
                      high-specific-activity (HSA) 99Mo produced in nuclear
                      reactors. However, recent reactor shutdowns have led to
                      supply shortages and prompted efforts to implement
                      alternative production methods. One promising approach is
                      neutron activation of 98Mo, which yields
                      low-specific-activity (LSA) 99Mo. Since conventional
                      Al2O3-based 99Mo/99mTc generators are designed for HSA 99Mo,
                      adaptations are required for LSA 99Mo usage. In this study,
                      we evaluated the feasibility of modifying existing
                      Al2O3-based 99Mo/99mTc generators for use with LSA 99Mo,
                      anticipating production at the planned high brilliance
                      neutron source (HBS) at Forschungszentrum Jülich. Key
                      modifications included adjustments to the amount of Al2O3 on
                      the column and the elution volume of 99mTc to enhance 99Mo
                      adsorption and 99mTc elution efficiency. The performance of
                      the modified “mock-up” system was compared with a
                      standard clinical generator. The results demonstrated that
                      only minor modifications are required for LSA 99Mo to be
                      effectively utilized in a future generator, with elution
                      efficiencies remaining comparable to conventional
                      generators, while maintaining parameters like size, form,
                      number, activity of the individual generator comparable.
                      However, 99Mo breakthrough levels exceeded regulatory
                      limits, highlighting the need for further optimization.
                      Nevertheless, these findings support the feasibility of
                      using LSA 99Mo in clinical applications with minimal changes
                      to existing infrastructure.},
      cin          = {INM-5},
      ddc          = {540},
      cid          = {I:(DE-Juel1)INM-5-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1007/s10967-025-10423-5},
      url          = {https://juser.fz-juelich.de/record/1048136},
}