001048423 001__ 1048423
001048423 005__ 20251205115707.0
001048423 037__ $$aFZJ-2025-04634
001048423 1001_ $$0P:(DE-Juel1)130797$$aLettinga, M.P.$$b0$$eCorresponding author$$ufzj
001048423 1112_ $$aInternational Workshop on Advances in Mechanobiology$$cNapoli$$d2025-04-27 - 2025-04-30$$gadmechbio2025$$wItaly
001048423 245__ $$aEffect of true 3D vascular structures on the flow of aggregating red blood cells
001048423 260__ $$c2025
001048423 3367_ $$033$$2EndNote$$aConference Paper
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001048423 3367_ $$0PUB:(DE-HGF)6$$2PUB:(DE-HGF)$$aConference Presentation$$bconf$$mconf$$s1764932188_22749$$xAfter Call
001048423 520__ $$aThe significance of healthy blood vessels and blood flow for proper brain functioning is key in the development of human neurodegenerative disorders. Therefore, it is of interest to develop a platform to investigate blood flow through the brain vasculature.  Though the understanding of the flow dynamics greatly advanced with  the introduction of 2-D microfluidics, these channels are inherently different from the physiological vessels.  Here we introduce Selective Laser-induced Etching (SLE) as a novel technique  to produce full 3-D microfluidic geometries in glass with any desirable shape to study the flow dynamics of dispersions of aggregating  Red Blood Cells. We apply this technique to study the effect of distortion of the flow by a bifurcation as probed by a second generation of bifurcations, one of which being in-plane and one of which being out-of-plane with the first  bifurcation. We find that the distortion of the flow due to the first bifurcation relaxes in the branch with the out-of-plane bifurcation, whereas it does not relax in the branch with the in-plane bifurcation, as is the case in 2D microfluidic experiments. This difference in flow behaviour between both branches is only observed when the red blood cells are aggregated [1]. In addition, we excavated a trifurcation, as reconstructed from a human brain image. These experiments not only exemplify the possibilities of the technique, but they also show that asymmetry in the vessel geometry strongly impacts the flow behavior.
001048423 536__ $$0G:(DE-HGF)POF4-5243$$a5243 - Information Processing in Distributed Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
001048423 7001_ $$0P:(DE-Juel1)177939$$aGholivand, Amirreza$$b1
001048423 7001_ $$0P:(DE-Juel1)133649$$aDahlhoff, Knut$$b2$$ufzj
001048423 7001_ $$0P:(DE-Juel1)165746$$aDickscheid, Timo$$b3$$ufzj
001048423 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)130797$$aForschungszentrum Jülich$$b0$$kFZJ
001048423 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)133649$$aForschungszentrum Jülich$$b2$$kFZJ
001048423 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)165746$$aForschungszentrum Jülich$$b3$$kFZJ
001048423 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5243$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
001048423 9141_ $$y2025
001048423 920__ $$lyes
001048423 9201_ $$0I:(DE-Juel1)IBI-4-20200312$$kIBI-4$$lBiomakromolekulare Systeme und Prozesse$$x0
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001048423 980__ $$aI:(DE-Juel1)IBI-4-20200312
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