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@INPROCEEDINGS{Lettinga:1048423,
      author       = {Lettinga, M.P. and Gholivand, Amirreza and Dahlhoff, Knut
                      and Dickscheid, Timo},
      title        = {{E}ffect of true 3{D} vascular structures on the flow of
                      aggregating red blood cells},
      reportid     = {FZJ-2025-04634},
      year         = {2025},
      abstract     = {The significance of healthy blood vessels and blood flow
                      for proper brain functioning is key in the development of
                      human neurodegenerative disorders. Therefore, it is of
                      interest to develop a platform to investigate blood flow
                      through the brain vasculature. Though the understanding of
                      the flow dynamics greatly advanced with the introduction of
                      2-D microfluidics, these channels are inherently different
                      from the physiological vessels. Here we introduce Selective
                      Laser-induced Etching (SLE) as a novel technique to produce
                      full 3-D microfluidic geometries in glass with any desirable
                      shape to study the flow dynamics of dispersions of
                      aggregating Red Blood Cells. We apply this technique to
                      study the effect of distortion of the flow by a bifurcation
                      as probed by a second generation of bifurcations, one of
                      which being in-plane and one of which being out-of-plane
                      with the first bifurcation. We find that the distortion of
                      the flow due to the first bifurcation relaxes in the branch
                      with the out-of-plane bifurcation, whereas it does not relax
                      in the branch with the in-plane bifurcation, as is the case
                      in 2D microfluidic experiments. This difference in flow
                      behaviour between both branches is only observed when the
                      red blood cells are aggregated [1]. In addition, we
                      excavated a trifurcation, as reconstructed from a human
                      brain image. These experiments not only exemplify the
                      possibilities of the technique, but they also show that
                      asymmetry in the vessel geometry strongly impacts the flow
                      behavior.},
      month         = {Apr},
      date          = {2025-04-27},
      organization  = {International Workshop on Advances in
                       Mechanobiology, Napoli (Italy), 27 Apr
                       2025 - 30 Apr 2025},
      subtyp        = {After Call},
      cin          = {IBI-4},
      cid          = {I:(DE-Juel1)IBI-4-20200312},
      pnm          = {5243 - Information Processing in Distributed Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5243},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1048423},
}