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001048674 1001_ $$0P:(DE-HGF)0$$aReichard, Julia$$b0
001048674 245__ $$aDNMT1-mediated regulation of somatostatin-positive interneuron migration impacts cortical architecture and function
001048674 260__ $$a[London]$$bSpringer Nature$$c2025
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001048674 520__ $$aThe coordinated development of cortical circuits composed of excitatory and inhibitory neurons is critical for proper brain function, and disruptions are linked to a spectrum of neuropsychiatric disorders. While excitatory neurons are generated locally in the cortical proliferative zones, inhibitory cortical interneurons (cINs) originate in the basal telencephalon and migrate tangentially into the cortex. Here, we show that DNA methyltransferase 1 (DNMT1) is essential for the migration and integration of somatostatin (SST)-expressing interneurons in mice. Dnmt1 deletion causes premature exit of SST+ cINs from the superficial migratory stream and alters the expression of key developmental genes. Unexpectedly, Dnmt1-deficient SST+ interneurons also exert non-cell-autonomous effects on cortical progenitor cells, resulting in subtle yet lasting alterations in cortical layering. These findings propose a role for DNMT1 in governing the migration of SST+ interneurons and mediating their instructive signaling to cortical progenitor cells, thereby shaping cortical architecture and influencing long-term network function.
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001048674 7001_ $$0P:(DE-HGF)0$$aWolff, Philip$$b1
001048674 7001_ $$0P:(DE-Juel1)201922$$aXie, Song$$b2
001048674 7001_ $$0P:(DE-HGF)0$$aZuo, Ke$$b3
001048674 7001_ $$0P:(DE-HGF)0$$aFullio, Camila L.$$b4
001048674 7001_ $$0P:(DE-HGF)0$$aDu, Jian$$b5
001048674 7001_ $$0P:(DE-Juel1)186078$$aGraff, Severin$$b6
001048674 7001_ $$0P:(DE-HGF)0$$aLinde, Jenice$$b7
001048674 7001_ $$0P:(DE-HGF)0$$aYildiz, Can Bora$$b8
001048674 7001_ $$0P:(DE-HGF)0$$aPitschelatow, Georg$$b9
001048674 7001_ $$0P:(DE-HGF)0$$aNabbefeld, Gerion$$b10
001048674 7001_ $$0P:(DE-HGF)0$$aDorp, Lilli$$b11
001048674 7001_ $$0P:(DE-HGF)0$$aVollmer, Johanna$$b12
001048674 7001_ $$0P:(DE-HGF)0$$aBiemans, Linda$$b13
001048674 7001_ $$0P:(DE-HGF)0$$aKempf, Shirley$$b14
001048674 7001_ $$0P:(DE-HGF)0$$aSingh, Minali$$b15
001048674 7001_ $$0P:(DE-HGF)0$$aMohan, K. Naga$$b16
001048674 7001_ $$0P:(DE-HGF)0$$aKuo, Chao-Chung$$b17
001048674 7001_ $$0P:(DE-HGF)0$$aVogel, Tanja$$b18
001048674 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b19
001048674 7001_ $$0P:(DE-Juel1)175146$$aMusall, Simon$$b20
001048674 7001_ $$0P:(DE-HGF)0$$aZimmer-Bensch, Geraldine$$b21$$eCorresponding author
001048674 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-62114-0$$gVol. 16, no. 1, p. 6834$$n1$$p6834$$tNature Communications$$v16$$x2041-1723$$y2025
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