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@ARTICLE{Reichard:1048674,
      author       = {Reichard, Julia and Wolff, Philip and Xie, Song and Zuo, Ke
                      and Fullio, Camila L. and Du, Jian and Graff, Severin and
                      Linde, Jenice and Yildiz, Can Bora and Pitschelatow, Georg
                      and Nabbefeld, Gerion and Dorp, Lilli and Vollmer, Johanna
                      and Biemans, Linda and Kempf, Shirley and Singh, Minali and
                      Mohan, K. Naga and Kuo, Chao-Chung and Vogel, Tanja and
                      Carloni, Paolo and Musall, Simon and Zimmer-Bensch,
                      Geraldine},
      title        = {{DNMT}1-mediated regulation of somatostatin-positive
                      interneuron migration impacts cortical architecture and
                      function},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2025-04797},
      pages        = {6834},
      year         = {2025},
      abstract     = {The coordinated development of cortical circuits composed
                      of excitatory and inhibitory neurons is critical for proper
                      brain function, and disruptions are linked to a spectrum of
                      neuropsychiatric disorders. While excitatory neurons are
                      generated locally in the cortical proliferative zones,
                      inhibitory cortical interneurons (cINs) originate in the
                      basal telencephalon and migrate tangentially into the
                      cortex. Here, we show that DNA methyltransferase 1 (DNMT1)
                      is essential for the migration and integration of
                      somatostatin (SST)-expressing interneurons in mice. Dnmt1
                      deletion causes premature exit of SST+ cINs from the
                      superficial migratory stream and alters the expression of
                      key developmental genes. Unexpectedly, Dnmt1-deficient SST+
                      interneurons also exert non-cell-autonomous effects on
                      cortical progenitor cells, resulting in subtle yet lasting
                      alterations in cortical layering. These findings propose a
                      role for DNMT1 in governing the migration of SST+
                      interneurons and mediating their instructive signaling to
                      cortical progenitor cells, thereby shaping cortical
                      architecture and influencing long-term network function.},
      cin          = {INM-9 / IBI-3},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-9-20140121 / I:(DE-Juel1)IBI-3-20200312},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525) / 5231 -
                      Neuroscientific Foundations (POF4-523)},
      pid          = {G:(DE-HGF)POF4-5252 / G:(DE-HGF)POF4-5231},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s41467-025-62114-0},
      url          = {https://juser.fz-juelich.de/record/1048674},
}