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@MISC{Dickscheid:1048778,
author = {Dickscheid, Timo and Bludau, Sebastian},
title = {{W}orking with quantitative cortical cell densities using
siibra},
reportid = {FZJ-2025-04893},
year = {2025},
abstract = {The regional microstructure of cortical brain areas, along
with their connectivity to other regions, is linked to their
functional profile. Consequently, microstructure varies
significantly between different brain region. Along with
modern image analysis methods, the BigBrain provides a
unique resource for quantifying microstructure in terms of
numbers, densities, and distributions of cell bodies at
different locations in the brain. In this tutorial, we
demonstrate how the siibra toolsuite can be used to access
micrometer resolution BigBrain image data and extract
cortical image patches for custom regions of interest. We
will show how locations can be specified or sampled in
interactive and scripted workflows, and demonstrate how
state of the art AI models can be used to extract and
quantify cell instances from extracted image patches in a
reproducible fashion. We will present a dataset of
layer-specific cell densities for areas defined in the
Julich-Brain cytoarchitectonic atlas, which has been created
on the basis of these ideas and is available through
siibra.},
month = {Oct},
date = {2025-10-27},
organization = {9th BigBrain Workshop - HIBALL Closing
Symposium, Berlin (Germany), 27 Oct
2025 - 27 Oct 2025},
subtyp = {Invited},
cin = {INM-1},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {5254 - Neuroscientific Data Analytics and AI (POF4-525) /
5251 - Multilevel Brain Organization and Variability
(POF4-525) / HIBALL - Helmholtz International BigBrain
Analytics and Learning Laboratory (HIBALL) (InterLabs-0015)
/ EBRAINS 2.0 - EBRAINS 2.0: A Research Infrastructure to
Advance Neuroscience and Brain Health (101147319)},
pid = {G:(DE-HGF)POF4-5254 / G:(DE-HGF)POF4-5251 /
G:(DE-HGF)InterLabs-0015 / G:(EU-Grant)101147319},
typ = {PUB:(DE-HGF)17},
url = {https://juser.fz-juelich.de/record/1048778},
}