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@ARTICLE{Rostampour:1048884,
      author       = {Rostampour, Masoumeh and Apter, Daryna and Rostampour, Ali
                      and Khosravi-Bayangani, Shayesteh and Elberse, Jorik D. and
                      Sharafkhaneh, Amir and Khazaie, Habibolah and Tahmasian,
                      Masoud},
      title        = {{A}lterations of neurofluid transport in patients with
                      obstructive sleep apnea and insomnia disorder},
      journal      = {Sleep medicine},
      volume       = {138},
      issn         = {1389-9457},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2025-04989},
      pages        = {108687 -},
      year         = {2026},
      abstract     = {Sleep appears to modulate brain-wide neurofluid transport,
                      encompassing the movement and exchange of cerebrospinal and
                      interstitial fluids via perivascular pathways. However,
                      neurofluid transport in common sleep disorders, such as
                      insomnia disorder and obstructive sleep apnea, requires
                      further assessment. In this study, we recruited 159
                      participants: patients with moderate to severe obstructive
                      sleep apnea (n = 36) or chronic insomnia disorder (n = 62),
                      and healthy controls (n = 61). Participants underwent
                      structural magnetic resonance imaging, polysomnography, the
                      Pittsburgh Sleep Quality Index, and the STOP-Bang
                      questionnaires. Here, neurofluid transport is indirectly
                      assessed using two noninvasive MRI indices (i.e., the
                      perivascular space volume fraction and diffusion tensor
                      imaging along perivascular spaces). Patients with
                      obstructive sleep apnea exhibited a significantly larger
                      perivascular space volume fraction compared with patients
                      with insomnia disorder (p = 0.042) and healthy controls (p =
                      0.032), whereas no group differences were observed for the
                      diffusion-based index. Partial correlation analyses,
                      adjusted for age, sex, and body mass index, revealed that in
                      obstructive sleep apnea, a larger perivascular space volume
                      fraction was associated with less sleep disturbance (r =
                      −0.35, p = 0.04), and diffusion measures increased with
                      snoring severity (r = 0.38, p = 0.03). In insomnia disorder,
                      a larger perivascular space volume fraction was associated
                      with a higher nocturnal wake index (r = 0.38, p = 0.006) and
                      an elevated risk of blood pressure (r = 0.50, p < 0.001),
                      while inversely relating to subjective sleep quality (r =
                      −0.35, p = 0.01). Our results highlight different patterns
                      of neurofluid transport alterations across obstructive sleep
                      apnea and insomnia disorder.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.sleep.2025.108687},
      url          = {https://juser.fz-juelich.de/record/1048884},
}