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001048894 0247_ $$2doi$$a10.1007/s00259-025-07654-9
001048894 0247_ $$2ISSN$$a1619-7070
001048894 0247_ $$2ISSN$$a1619-7089
001048894 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-04995
001048894 037__ $$aFZJ-2025-04995
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001048894 1001_ $$00000-0001-7147-4594$$aWerner, Jan-Michael$$b0$$eFirst author
001048894 245__ $$aClinical potential of [18F]FET PET in patients with circumscribed astrocytic glioma
001048894 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2026
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001048894 500__ $$aFunding Open access funding provided by Medical University of Vienna. Funded by the research budget of the Medical University of Vienna. Financial support by the Austrian Federal Ministry for Digital and Economic Affairs, the National Foundation for Research, Technologyand Development and the Christian Doppler Research Association is gratefully acknowledged. Supported by personal funding (J-M.W.) from the German Cancer Aid (Deutsche Krebshilfe). M.J.M. acknowledges personal funding from the European Society of Medical Oncology(ESMO) through a Translational Research Fellowship. This project was supported by Nuclear Medicine and Neurooncology (NMN).Eur J Nucl Med Mol Imaging 2025 Nov 18. doi: 10.1007/s00259-025-07654-9. Online ahead of print. Published online 18 Nov 2025
001048894 520__ $$aPurposeTo investigate the clinical potential of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) PET imaging in the management of circumscribed astrocytic gliomas (CAG), a rare glioma subtype with limited imaging data.MethodsWe retrospectively identified adult CAG patients who underwent [18F]FET PET imaging (i) before diagnosis, (ii) at suspected relapse, or (iii) for response assessment at three institutions. Maximum and mean tumor-to-brain ratios (TBRmax, TBRmean) and metabolic tumor volumes were assessed according to the PET RANO 1.0 criteria. Diagnostic performance in differentiating treatment-related changes from tumor relapse was evaluated using ROC analysis and Fisher’s exact test.ResultsWe evaluated 79 [18F]FET PET scans of 42 patients, including nine (21%) with actionable molecular targets. Measurable [18F]FET uptake was observed in 65% of WHO grade 1 and 100% of WHO grade 2 and 3 CAG. TBR values were significantly higher in WHO grade 2 and 3 CAG than in pilocytic astrocytomas (P < 0.01), but showed no difference based on molecular target status (P > 0.05). In 5 of 11 patients (45%), treatment response assessment by PET RANO 1.0 differed from MRI. Treatment-related changes were confirmed in 12 patients (43%). In CAG WHO grades 2 or 3, the accuracy of [18F]FET PET to identify treatment-related changes was 82% using single PET scans and 100% using serial PET imaging (P < 0.05).Conclusions[18F]FET PET can contribute to clinical management of patients with CAG by detecting measurable disease, differentiating treatment-related changes from tumor progression, and showing potential in treatment response assessment through longitudinal imaging.
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001048894 7001_ $$00000-0002-6537-3874$$aMair, Maximilian J.$$b1
001048894 7001_ $$0P:(DE-Juel1)190394$$aWollring, Michael M.$$b2
001048894 7001_ $$0P:(DE-HGF)0$$aBarci, Enio$$b3
001048894 7001_ $$00009-0007-1732-5759$$aStetter, Isabelle$$b4
001048894 7001_ $$00000-0002-7203-8732$$aPuhr, Hannah C.$$b5
001048894 7001_ $$aTscherpel, Caroline$$b6
001048894 7001_ $$0P:(DE-Juel1)131627$$aStoffels, Gabriele$$b7
001048894 7001_ $$0P:(DE-HGF)0$$aHainfellner, Johannes A.$$b8
001048894 7001_ $$00000-0001-9379-6797$$aBerghoff, Anna S.$$b9
001048894 7001_ $$0P:(DE-HGF)0$$aSunder-Plassmann, Vincent$$b10
001048894 7001_ $$00000-0001-6014-0273$$aWidhalm, Georg$$b11
001048894 7001_ $$0P:(DE-HGF)0$$aEckert, Franziska$$b12
001048894 7001_ $$0P:(DE-HGF)0$$aKasprian, Gregor$$b13
001048894 7001_ $$0P:(DE-HGF)0$$aNakuz, Thomas S.$$b14
001048894 7001_ $$0P:(DE-HGF)0$$aBeck, Alexander$$b15
001048894 7001_ $$0P:(DE-HGF)0$$aHarter, Patrick N.$$b16
001048894 7001_ $$00000-0002-6634-0927$$avon Baumgarten, Louisa$$b17
001048894 7001_ $$0P:(DE-HGF)0$$aThon, Niklas$$b18
001048894 7001_ $$0P:(DE-HGF)0$$aSchönecker, Stephan$$b19
001048894 7001_ $$0P:(DE-HGF)0$$aForbrig, Robert$$b20
001048894 7001_ $$0P:(DE-Juel1)132318$$aMottaghy, Felix M.$$b21
001048894 7001_ $$0P:(DE-Juel1)145110$$aLohmann, Philipp$$b22
001048894 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b23
001048894 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b24
001048894 7001_ $$0P:(DE-Juel1)143792$$aGalldiks, Norbert$$b25
001048894 7001_ $$00000-0003-0953-7624$$aAlbert, Nathalie L.$$b26
001048894 7001_ $$00000-0003-3541-2315$$aPreusser, Matthias$$b27$$eCorresponding author
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