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@INPROCEEDINGS{Caspari:1048932,
      author       = {Caspari, Benedict and Bittner, Nora and Miller, Tatiana and
                      Dellani, Paulo R. and Caspers, Svenja},
      title        = {{M}icroarchitectural differences between {W}hite {M}atter
                      {L}esions and {N}ormal-{A}ppearing {W}hite {M}atter across
                      {A}rterial {T}erritories: {I}nsights from {N}eurite
                      {O}rientation {D}ispersion and {D}ensity {I}maging},
      reportid     = {FZJ-2025-05029},
      year         = {2025},
      abstract     = {White Matter Lesions (WML) are linked to aging and vascular
                      risk factors, while their microstructural mechanisms remain
                      largely unclear. Using Neurite Orientation Dispersion and
                      Density Imaging (NODDI), we investigated microarchitectural
                      properties in WML in 915 participants $(47\%$ female, ages
                      18-85) from the population-based 1000BRAINS
                      study.Microstructural properties, i.e. FA, extracellular
                      volume fraction (ECVF), neurite density (ICVF) and
                      dispersion (ODI) were derived from T1- and
                      diffusion-weighted MRI for WML and normal-appearing white
                      matter (NAWM). Within-person differences between WML and
                      NAWM were calculated for each property and related to age,
                      cardiovascular risk (e.g., blood pressure), and vascular
                      supply. Older age is associated with increased ECVF and ODI
                      differences, but smaller ICVF differences. Mostly similar
                      patterns were found for higher cardiovascular risk. In
                      contrast to expectations, FA differences decreased with age.
                      Compared to NAWM, WML show an increased ECVF in
                      anterior-supplied, while ICVF in medial-supplied and ODI in
                      posterior-supplied cerebral artery regions decrease.
                      Together, our data indicate a non-uniform distribution of
                      microstructural changes in WML across vascular territories,
                      with additional variation linked to cardiovascular risk and
                      age. Overall, the data suggest a greater reduction in
                      neurite density in WML compared to NAWM in relation to older
                      age.},
      month         = {May},
      date          = {2025-05-07},
      organization  = {Aging and Cognition Conference, Pavia
                       (Italy), 7 May 2025 - 10 May 2025},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://juser.fz-juelich.de/record/1048932},
}