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@INPROCEEDINGS{Miller:1048933,
      author       = {Miller, Tatiana and Bittner, Nora and Dellani, Paulo R. and
                      Quabs, Julian and Caspers, Svenja},
      title        = {{W}hite {M}atter {L}esions spatial distribution patterns
                      related to cardiovascular aging follow arterial supply
                      territories},
      reportid     = {FZJ-2025-05030},
      year         = {2025},
      abstract     = {White matter lesions (WML) in brain MRI scans are common in
                      older adults and are linked to cognitive, mood, and motor
                      disorders, as well as increased risks of dementia and
                      stroke. These lesions are influenced by lifestyle and
                      cardiovascular factors. To explore the relationship between
                      cardiovascular health and WML spatial distribution, we
                      analysed the similarity between participants using k-means
                      clustering, based on WML center location, WML burden, and
                      cardiovascular health status, in two population-based
                      cohorts: 1000BRAINS (n=1,040, ages 18-85) and NAKO
                      (n=27,559, ages 19-74). Cardiovascular health status was
                      summarized using a ‘cardiovascular age’ score, which
                      included age, sex, blood pressure, hypertension medication,
                      smoking status, diabetes diagnosis, and cholesterol levels.
                      We mapped the affected brain areas on the Digital 3D Brain
                      MRI Arterial Territories Atlas and tested each cluster’s
                      mean WML distribution, surpassing $95\%$ bootstrap
                      confidence.Our findings revealed five distinct WML spatial
                      distribution patterns in each cohort, four of which were
                      common across both. These patterns highlighted specific
                      arterial territories with varying degrees of WML presence,
                      providing evidence that WML spatial distributions are
                      influenced by cardiovascular aging. Additionally, the medial
                      lenticulostriate territory emerged as the first arterial
                      region affected in normal aging.},
      month         = {May},
      date          = {2025-05-07},
      organization  = {Aging and Cognition Conference, Pavia
                       (Italy), 7 May 2025 - 10 May 2025},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)1},
      url          = {https://juser.fz-juelich.de/record/1048933},
}