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@INPROCEEDINGS{Zhukova:1048938,
      author       = {Zhukova, Natalia and Mendl-Heinisch, Camilla and Jockwitz,
                      Christiane and Caspers, Svenja},
      title        = {{R}educed dynamic functional connectivity in higher ages:
                      are older brains less adaptable?},
      reportid     = {FZJ-2025-05035},
      year         = {2025},
      abstract     = {Static functional connectivity (FC) approaches, assuming
                      constant interactions between brain regions, revealed
                      important insights into the aging process. Nevertheless,
                      recent research has indicated that a more sophisticated
                      understanding of the time-varying nature of brain function
                      may prove particularly useful in identifying biomarkers for
                      healthy aging.The current study therefore investigated
                      dynamic FC (dFC) in a large group of older adults
                      (1000BRAINS; n=817; 373 females; 55-85 years; MAge=67±7).
                      Time-varying correlation matrices and dFC states were
                      extracted from resting-state fMRI using sliding windows and
                      clustering. We examined both, temporal features of dFC
                      states, e.g. duration and transitions, together with
                      age-related differences in network architecture (17 networks
                      Schaefer parcellation). We found four distinct dFC states,
                      of which two showed agesensitive patterns. The first was
                      distinguished by highly connected networks and became less
                      prevalent with age. In contrast, the second state was
                      characterized by reduced network connectivity, becoming more
                      prevalent with age. Together with a decline in transition
                      between states, the results underscore an age-related
                      reduction in overall network communication and a reduced
                      capacity for functional adaptation. The findings challenge
                      the conventional understanding of brain network interactions
                      by emphasizing the dynamic adaptability of the brain in
                      explaining variations in cognitive functioning.},
      month         = {May},
      date          = {2025-05-07},
      organization  = {Aging and Cognition Conference, Pavia
                       (Italy), 7 May 2025 - 10 May 2025},
      subtyp        = {After Call},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / HBP SGA3 - Human Brain Project Specific Grant
                      Agreement 3 (945539)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(EU-Grant)945539},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/1048938},
}