001048964 001__ 1048964
001048964 005__ 20251209202151.0
001048964 0247_ $$2doi$$a10.1101/2025.11.19.689337
001048964 037__ $$aFZJ-2025-05061
001048964 1001_ $$0P:(DE-Juel1)177822$$aPaas Oliveros, Lya K.$$b0$$eCorresponding author
001048964 245__ $$aUnveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting
001048964 260__ $$c2025
001048964 3367_ $$0PUB:(DE-HGF)25$$2PUB:(DE-HGF)$$aPreprint$$bpreprint$$mpreprint$$s1765263570_1843
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001048964 3367_ $$2BibTeX$$aARTICLE
001048964 3367_ $$2DataCite$$aOutput Types/Working Paper
001048964 520__ $$aThe left dorsolateral prefrontal cortex (lDLPFC) is the standard target for transcranial magnetic stimulation (TMS) to ameliorate treatment-resistant depression (TRD), yet non-response rates remain high. TMS efficacy has been linked to the stimulation site’s functional connectivity, particularly its anti-correlation with the subgenual cingulate cortex (SGC). While this pragmatic strategy has demonstrated clinical utility, it offers limited insight into how the lDLPFC’s network interactions contribute to site-dependent variability in treatment response. Here, we used connectivity-based parcellation within an lDLPFC region encompassing common TMS targets and adjacent areas to delineate functional subdivisions and characterize their connectivity to large-scale networks and behavioral associations. Our results revealed a hierarchical organization: a coarse two-pole antagonism between anterior-central and superior-posterior subregions and a finer nine-cluster architecture exposing lDLPFC’s heterogeneity along anterior-posterior and ventral-dorsal axes. Anterior-central areas were strongly anti-correlated with SGC and default-mode network, positively connected with salience, dorsal attention, and control networks, and associated with cognitive control. In contrast, superior-posterior subregions displayed the inverse pattern, while ventral clusters engaged somatomotor and visual networks, and language-related processes. Central and superior-anterior clusters showed differentiated profiles, including associations with inhibition, social cognition, and perceptual functions. To aid clinical translation, we derived an lDLPFC likelihood map integrating granularities, highlighting anterior-central lDLPFC as the strongest TMS candidate considering the relevance of its connectivity and behavioral profiles to depression, while indicating that neighboring subregions have distinct functions. These findings underscore the lDLPFC’s hierarchical and heterogeneous organization and provide a network-informed reference for developing individualized, symptom-specific TMS interventions.
001048964 536__ $$0G:(DE-HGF)POF4-5252$$a5252 - Brain Dysfunction and Plasticity (POF4-525)$$cPOF4-525$$fPOF IV$$x0
001048964 588__ $$aDataset connected to CrossRef
001048964 7001_ $$0P:(DE-HGF)0$$aPoeppl, Timm B.$$b1
001048964 7001_ $$0P:(DE-Juel1)170074$$aReuter, Niels$$b2
001048964 7001_ $$0P:(DE-Juel1)172843$$aPatil, Kaustubh R.$$b3
001048964 7001_ $$0P:(DE-HGF)0$$aKreuzer, Sarah$$b4
001048964 7001_ $$0P:(DE-HGF)0$$aTse, Nga Yan$$b5
001048964 7001_ $$0P:(DE-HGF)0$$aCash, Robin F. H.$$b6
001048964 7001_ $$0P:(DE-Juel1)131684$$aHoffstaedter, Felix$$b7
001048964 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b8
001048964 7001_ $$0P:(DE-Juel1)131699$$aMüller, Veronika I.$$b9$$eCorresponding author
001048964 773__ $$a10.1101/2025.11.19.689337
001048964 909CO $$ooai:juser.fz-juelich.de:1048964$$pVDB
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001048964 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131684$$aForschungszentrum Jülich$$b7$$kFZJ
001048964 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b8$$kFZJ
001048964 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131678$$a HHU Düsseldorf$$b8
001048964 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131699$$aForschungszentrum Jülich$$b9$$kFZJ
001048964 9131_ $$0G:(DE-HGF)POF4-525$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5252$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vDecoding Brain Organization and Dysfunction$$x0
001048964 9141_ $$y2025
001048964 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
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