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001048979 0247_ $$2ISSN$$a1872-7123
001048979 0247_ $$2ISSN$$a1872-7506
001048979 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-05074
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001048979 1001_ $$0P:(DE-HGF)0$$aGreiner, Sophie-Kathrin$$b0$$eCorresponding author
001048979 245__ $$aHow childhood adversities shape minds and lives: An analysis across the affective-to-psychotic spectrum.
001048979 260__ $$aAmsterdam$$bElsevier$$c2025
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001048979 520__ $$aAdverse childhood experiences (ACE) contribute significantly to mental disorders. While existing research has primarily focused on specific diagnostic categories, a comprehensive understanding of how childhood trauma interacts with biological factors, symptom severity and functioning requires a broader perspective. Therefore, this study adopted a cross-diagnostic approach to examine the impact of ACE on quality of life (QoL), psychosocial functioning, and symptom burden by analyzing data from the PsyCourse Study, a longitudinal, multicenter research project conducted in Germany and Austria. We used multivariate linear regression models and cluster analysis to evaluate data from 725 participants with affective and psychotic disorders and healthy controls who completed the self-assessed Childhood Trauma Screener (CTS) during the course of the study. The results showed that across diagnoses, QoL was significantly impacted by ACE, particularly emotional neglect. An ablation study revealed that 2.3 % to 6.2 % of the variability in QoL domains could be attributed to ACE. Across diagnoses, symptoms of depression were significantly associated with ACE, especially emotional abuse, but psychotic and manic symptoms were not. Polygenic risk scores (PRS) did not emerge as significant predictors for any examined outcomes. Cluster analysis revealed distinct symptom profiles: Averaged over time, patients with less trauma exposure were rather in the subclinical than in the clinically ill clusters. We conclude that the pervasive influence of ACE on disease severity should be considered when evaluating and treating patients with affective and psychotic disorders.
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001048979 650_7 $$2Other$$aAdverse childhood experiences
001048979 650_7 $$2Other$$aAffective disorders
001048979 650_7 $$2Other$$aGlobal functioning
001048979 650_7 $$2Other$$aPsychotic disorders
001048979 650_7 $$2Other$$aQuality of life
001048979 650_2 $$2MeSH$$aHumans
001048979 650_2 $$2MeSH$$aMale
001048979 650_2 $$2MeSH$$aFemale
001048979 650_2 $$2MeSH$$aAdult
001048979 650_2 $$2MeSH$$aAdverse Childhood Experiences: statistics & numerical data
001048979 650_2 $$2MeSH$$aQuality of Life: psychology
001048979 650_2 $$2MeSH$$aPsychotic Disorders: psychology
001048979 650_2 $$2MeSH$$aPsychotic Disorders: etiology
001048979 650_2 $$2MeSH$$aPsychotic Disorders: physiopathology
001048979 650_2 $$2MeSH$$aLongitudinal Studies
001048979 650_2 $$2MeSH$$aMiddle Aged
001048979 650_2 $$2MeSH$$aGermany
001048979 650_2 $$2MeSH$$aYoung Adult
001048979 650_2 $$2MeSH$$aAustria
001048979 650_2 $$2MeSH$$aCluster Analysis
001048979 650_2 $$2MeSH$$aPsychosocial Functioning
001048979 650_2 $$2MeSH$$aAdolescent
001048979 650_2 $$2MeSH$$aChild
001048979 7001_ $$0P:(DE-HGF)0$$aPons, María Dech$$b1
001048979 7001_ $$0P:(DE-HGF)0$$aAblimit, Ayimnisagul$$b2
001048979 7001_ $$0P:(DE-HGF)0$$aBrauße, Elisa$$b3
001048979 7001_ $$0P:(DE-HGF)0$$aAdorjan, Kristina$$b4
001048979 7001_ $$aBudde, Monika$$b5
001048979 7001_ $$aHeilbronner, Maria$$b6
001048979 7001_ $$aHeilbronner, Urs$$b7
001048979 7001_ $$aKalman, Janos L$$b8
001048979 7001_ $$aNavarro-Flores, Alba$$b9
001048979 7001_ $$aKohshour, Mojtaba Oraki$$b10
001048979 7001_ $$aReich-Erkelenz, Daniela$$b11
001048979 7001_ $$aSchulte, Eva C$$b12
001048979 7001_ $$aVogl, Thomas$$b13
001048979 7001_ $$aAndlauer, Till$$b14
001048979 7001_ $$aAnghelescu, Ion-George$$b15
001048979 7001_ $$aArolt, Volker$$b16
001048979 7001_ $$aBaune, Bernhardt T$$b17
001048979 7001_ $$aDannlowski, Udo$$b18
001048979 7001_ $$aDegenhardt, Franziska$$b19
001048979 7001_ $$aDietrich, Detlef E$$b20
001048979 7001_ $$0P:(DE-HGF)0$$aFallgatter, Andreas J$$b21
001048979 7001_ $$0P:(DE-HGF)0$$aFigge, Christian$$b22
001048979 7001_ $$0P:(DE-Juel1)186755$$aForstner, Andreas$$b23
001048979 7001_ $$aJäger, Markus$$b24
001048979 7001_ $$aJuckel, Georg$$b25
001048979 7001_ $$aKonrad, Carsten$$b26
001048979 7001_ $$aNöthen, Markus M$$b27
001048979 7001_ $$aLang, Fabian U$$b28
001048979 7001_ $$aReimer, Jens$$b29
001048979 7001_ $$aReinighaus, Eva Z$$b30
001048979 7001_ $$aRietschel, Marcella$$b31
001048979 7001_ $$aSchmauß, Max$$b32
001048979 7001_ $$aSchmitt, Andrea$$b33
001048979 7001_ $$aSenner, Simon$$b34
001048979 7001_ $$aSpitzer, Carsten$$b35
001048979 7001_ $$aWiltfang, Jens$$b36
001048979 7001_ $$aWitt, Stephanie H$$b37
001048979 7001_ $$aZimmermann, Jörg$$b38
001048979 7001_ $$aHasan, Alkomiet$$b39
001048979 7001_ $$aFalkai, Peter$$b40
001048979 7001_ $$aSchulze, Thomas G$$b41
001048979 7001_ $$aPapiol, Sergi$$b42
001048979 7001_ $$aSenner, Fanny$$b43
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