TY  - JOUR
AU  - Greiner, Sophie-Kathrin
AU  - Pons, María Dech
AU  - Ablimit, Ayimnisagul
AU  - Brauße, Elisa
AU  - Adorjan, Kristina
AU  - Budde, Monika
AU  - Heilbronner, Maria
AU  - Heilbronner, Urs
AU  - Kalman, Janos L
AU  - Navarro-Flores, Alba
AU  - Kohshour, Mojtaba Oraki
AU  - Reich-Erkelenz, Daniela
AU  - Schulte, Eva C
AU  - Vogl, Thomas
AU  - Andlauer, Till
AU  - Anghelescu, Ion-George
AU  - Arolt, Volker
AU  - Baune, Bernhardt T
AU  - Dannlowski, Udo
AU  - Degenhardt, Franziska
AU  - Dietrich, Detlef E
AU  - Fallgatter, Andreas J
AU  - Figge, Christian
AU  - Forstner, Andreas
AU  - Jäger, Markus
AU  - Juckel, Georg
AU  - Konrad, Carsten
AU  - Nöthen, Markus M
AU  - Lang, Fabian U
AU  - Reimer, Jens
AU  - Reinighaus, Eva Z
AU  - Rietschel, Marcella
AU  - Schmauß, Max
AU  - Schmitt, Andrea
AU  - Senner, Simon
AU  - Spitzer, Carsten
AU  - Wiltfang, Jens
AU  - Witt, Stephanie H
AU  - Zimmermann, Jörg
AU  - Hasan, Alkomiet
AU  - Falkai, Peter
AU  - Schulze, Thomas G
AU  - Papiol, Sergi
AU  - Senner, Fanny
TI  - How childhood adversities shape minds and lives: An analysis across the affective-to-psychotic spectrum.
JO  - Psychiatry research / Neuroimaging
VL  - 350
SN  - 0925-4927
CY  - Amsterdam
PB  - Elsevier
M1  - FZJ-2025-05074
SP  - 116536 -
PY  - 2025
AB  - Adverse childhood experiences (ACE) contribute significantly to mental disorders. While existing research has primarily focused on specific diagnostic categories, a comprehensive understanding of how childhood trauma interacts with biological factors, symptom severity and functioning requires a broader perspective. Therefore, this study adopted a cross-diagnostic approach to examine the impact of ACE on quality of life (QoL), psychosocial functioning, and symptom burden by analyzing data from the PsyCourse Study, a longitudinal, multicenter research project conducted in Germany and Austria. We used multivariate linear regression models and cluster analysis to evaluate data from 725 participants with affective and psychotic disorders and healthy controls who completed the self-assessed Childhood Trauma Screener (CTS) during the course of the study. The results showed that across diagnoses, QoL was significantly impacted by ACE, particularly emotional neglect. An ablation study revealed that 2.3 % to 6.2 % of the variability in QoL domains could be attributed to ACE. Across diagnoses, symptoms of depression were significantly associated with ACE, especially emotional abuse, but psychotic and manic symptoms were not. Polygenic risk scores (PRS) did not emerge as significant predictors for any examined outcomes. Cluster analysis revealed distinct symptom profiles: Averaged over time, patients with less trauma exposure were rather in the subclinical than in the clinically ill clusters. We conclude that the pervasive influence of ACE on disease severity should be considered when evaluating and treating patients with affective and psychotic disorders.
KW  - Humans
KW  - Male
KW  - Female
KW  - Adult
KW  - Adverse Childhood Experiences: statistics & numerical data
KW  - Quality of Life: psychology
KW  - Psychotic Disorders: psychology
KW  - Psychotic Disorders: etiology
KW  - Psychotic Disorders: physiopathology
KW  - Longitudinal Studies
KW  - Middle Aged
KW  - Germany
KW  - Young Adult
KW  - Austria
KW  - Cluster Analysis
KW  - Psychosocial Functioning
KW  - Adolescent
KW  - Child
KW  - Adverse childhood experiences (Other)
KW  - Affective disorders (Other)
KW  - Global functioning (Other)
KW  - Psychotic disorders (Other)
KW  - Quality of life (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40424647
DO  - DOI:10.1016/j.psychres.2025.116536
UR  - https://juser.fz-juelich.de/record/1048979
ER  -