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@ARTICLE{Greiner:1048979,
      author       = {Greiner, Sophie-Kathrin and Pons, María Dech and Ablimit,
                      Ayimnisagul and Brauße, Elisa and Adorjan, Kristina and
                      Budde, Monika and Heilbronner, Maria and Heilbronner, Urs
                      and Kalman, Janos L and Navarro-Flores, Alba and Kohshour,
                      Mojtaba Oraki and Reich-Erkelenz, Daniela and Schulte, Eva C
                      and Vogl, Thomas and Andlauer, Till and Anghelescu,
                      Ion-George and Arolt, Volker and Baune, Bernhardt T and
                      Dannlowski, Udo and Degenhardt, Franziska and Dietrich,
                      Detlef E and Fallgatter, Andreas J and Figge, Christian and
                      Forstner, Andreas and Jäger, Markus and Juckel, Georg and
                      Konrad, Carsten and Nöthen, Markus M and Lang, Fabian U and
                      Reimer, Jens and Reinighaus, Eva Z and Rietschel, Marcella
                      and Schmauß, Max and Schmitt, Andrea and Senner, Simon and
                      Spitzer, Carsten and Wiltfang, Jens and Witt, Stephanie H
                      and Zimmermann, Jörg and Hasan, Alkomiet and Falkai, Peter
                      and Schulze, Thomas G and Papiol, Sergi and Senner, Fanny},
      title        = {{H}ow childhood adversities shape minds and lives: {A}n
                      analysis across the affective-to-psychotic spectrum.},
      journal      = {Psychiatry research / Neuroimaging},
      volume       = {350},
      issn         = {0925-4927},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2025-05074},
      pages        = {116536 -},
      year         = {2025},
      abstract     = {Adverse childhood experiences (ACE) contribute
                      significantly to mental disorders. While existing research
                      has primarily focused on specific diagnostic categories, a
                      comprehensive understanding of how childhood trauma
                      interacts with biological factors, symptom severity and
                      functioning requires a broader perspective. Therefore, this
                      study adopted a cross-diagnostic approach to examine the
                      impact of ACE on quality of life (QoL), psychosocial
                      functioning, and symptom burden by analyzing data from the
                      PsyCourse Study, a longitudinal, multicenter research
                      project conducted in Germany and Austria. We used
                      multivariate linear regression models and cluster analysis
                      to evaluate data from 725 participants with affective and
                      psychotic disorders and healthy controls who completed the
                      self-assessed Childhood Trauma Screener (CTS) during the
                      course of the study. The results showed that across
                      diagnoses, QoL was significantly impacted by ACE,
                      particularly emotional neglect. An ablation study revealed
                      that 2.3 $\%$ to 6.2 $\%$ of the variability in QoL domains
                      could be attributed to ACE. Across diagnoses, symptoms of
                      depression were significantly associated with ACE,
                      especially emotional abuse, but psychotic and manic symptoms
                      were not. Polygenic risk scores (PRS) did not emerge as
                      significant predictors for any examined outcomes. Cluster
                      analysis revealed distinct symptom profiles: Averaged over
                      time, patients with less trauma exposure were rather in the
                      subclinical than in the clinically ill clusters. We conclude
                      that the pervasive influence of ACE on disease severity
                      should be considered when evaluating and treating patients
                      with affective and psychotic disorders.},
      keywords     = {Humans / Male / Female / Adult / Adverse Childhood
                      Experiences: statistics $\&$ numerical data / Quality of
                      Life: psychology / Psychotic Disorders: psychology /
                      Psychotic Disorders: etiology / Psychotic Disorders:
                      physiopathology / Longitudinal Studies / Middle Aged /
                      Germany / Young Adult / Austria / Cluster Analysis /
                      Psychosocial Functioning / Adolescent / Child / Adverse
                      childhood experiences (Other) / Affective disorders (Other)
                      / Global functioning (Other) / Psychotic disorders (Other) /
                      Quality of life (Other)},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40424647},
      doi          = {10.1016/j.psychres.2025.116536},
      url          = {https://juser.fz-juelich.de/record/1048979},
}