001049046 001__ 1049046
001049046 005__ 20251211202156.0
001049046 0247_ $$2doi$$a10.1038/s44220-025-00486-4
001049046 0247_ $$2pmid$$apmid:41069367
001049046 0247_ $$2pmc$$apmc:PMC12504109
001049046 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-05141
001049046 037__ $$aFZJ-2025-05141
001049046 041__ $$aEnglish
001049046 082__ $$a610
001049046 1001_ $$00000-0002-0538-4774$$aShen, Xueyi$$b0
001049046 245__ $$aA methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison.
001049046 260__ $$aLondon$$bNature Publishing Group UK$$c2025
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001049046 520__ $$aMajor depression (MD) is a leading cause of global disease burden, and both experimental and population-based studies suggest that differences in DNA methylation may be associated with the condition. However, previous DNA methylation studies have, so far, not been widely replicated, suggesting a need for larger meta-analysis studies. Here we conducted a meta-analysis of methylome-wide association analysis for lifetime MD across 18 studies of 24,754 European-ancestry participants (5,443 MD cases) and an East Asian sample (243 cases, 1,846 controls). We identified 15 CpG sites associated with lifetime MD with methylome-wide significance. The methylation score created using the methylome-wide association analysis summary statistics was significantly associated with MD status in an out-of-sample classification analysis (area under the curve 0.53). Methylation score was also associated with five inflammatory markers, with the strongest association found with tumor necrosis factor beta. Mendelian randomization analysis revealed 23 CpG sites potentially causally linked to MD, with 7 replicated in an independent dataset. Our study provides evidence that variations in DNA methylation are associated with MD, and further evidence supporting involvement of the immune system.
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001049046 588__ $$aDataset connected to CrossRef, PubMed, , Journals: juser.fz-juelich.de
001049046 650_7 $$2Other$$aDNA methylation
001049046 650_7 $$2Other$$aDepression
001049046 650_7 $$2Other$$aEpigenomics
001049046 650_7 $$2Other$$aPredictive markers
001049046 7001_ $$0P:(DE-HGF)0$$aBarbu, Miruna$$b1
001049046 7001_ $$00000-0002-9740-871X$$aCaramaschi, Doretta$$b2
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001049046 7001_ $$00000-0001-7381-904X$$aCzamara, Darina$$b4
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001049046 7001_ $$00000-0001-9385-2015$$aDearman, Anna$$b6
001049046 7001_ $$aDilkes, Evelyn$$b7
001049046 7001_ $$00000-0001-7064-9487$$aHerrera-Rivero, Marisol$$b8
001049046 7001_ $$00000-0001-7776-7988$$aHuider, Floris$$b9
001049046 7001_ $$00000-0002-0158-8286$$aKühn, Luise$$b10
001049046 7001_ $$aLu, Kuan-Chen$$b11
001049046 7001_ $$00000-0002-7847-8384$$aPalviainen, Teemu$$b12
001049046 7001_ $$aSchowe, Alicia M$$b13
001049046 7001_ $$aShireby, Gemma$$b14
001049046 7001_ $$00000-0002-7113-0027$$aWeihs, Antoine$$b15
001049046 7001_ $$aWong, Chloe C Y$$b16
001049046 7001_ $$00000-0002-7313-0530$$aDavyson, Eleanor$$b17
001049046 7001_ $$aCasey, Hannah$$b18
001049046 7001_ $$00000-0002-3599-6018$$aAdams, Mark J$$b19
001049046 7001_ $$aAllgaier, Antje-Kathrin$$b20
001049046 7001_ $$aBarber, Michael$$b21
001049046 7001_ $$aBurrage, Joe$$b22
001049046 7001_ $$00000-0003-0082-4600$$aCaspi, Avshalom$$b23
001049046 7001_ $$aCosteira, Ricardo$$b24
001049046 7001_ $$00000-0003-1413-3229$$aDunn, Erin C$$b25
001049046 7001_ $$aFeldmann, Lisa$$b26
001049046 7001_ $$00000-0003-4867-9465$$aFrank, Josef$$b27
001049046 7001_ $$aFreisleder, Franz J$$b28
001049046 7001_ $$aGadd, Danni A$$b29
001049046 7001_ $$00000-0002-9916-9230$$aGreimel, Ellen$$b30
001049046 7001_ $$aHannon, Eilis$$b31
001049046 7001_ $$00000-0002-4941-5106$$aHarris, Sarah E$$b32
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001049046 7001_ $$00000-0003-4036-3642$$aCox, Simon R$$b59
001049046 7001_ $$00000-0002-0623-3759$$aDannlowski, Udo$$b60
001049046 7001_ $$aEvans, Kathryn L$$b61
001049046 7001_ $$00000-0003-4174-2126$$aFisher, Helen L$$b62
001049046 7001_ $$0P:(DE-Juel1)186755$$aForstner, Andreas J$$b63
001049046 7001_ $$aGrabe, Hans J$$b64
001049046 7001_ $$aKaprio, Jaakko$$b65
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001049046 7001_ $$00000-0002-0368-3930$$aKopf-Beck, Johannes$$b67
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001049046 7001_ $$aKuo, Po-Hsiu$$b69
001049046 7001_ $$aLi, Qingqin S$$b70
001049046 7001_ $$aMoffitt, Terrie E$$b71
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001049046 7001_ $$00000-0002-7647-2798$$aMurphy, Therese M$$b73
001049046 7001_ $$aSchulte-Körne, Gerd$$b74
001049046 7001_ $$aMill, Jonathan$$b75
001049046 7001_ $$00000-0002-8249-8476$$aLewis, Cathryn M$$b76
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001049046 7001_ $$00000-0001-7421-3357$$aWray, Naomi R$$b78
001049046 7001_ $$00000-0002-0198-4588$$aMcIntosh, Andrew M$$b79
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001049046 773__ $$0PERI:(DE-600)3123130-5$$a10.1038/s44220-025-00486-4$$gVol. 3, no. 10, p. 1152 - 1167$$n10$$p1152 - 1167$$tNature Mental Health$$v3$$x2731-6076$$y2025
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