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001049047 005__ 20251211202156.0
001049047 0247_ $$2doi$$a10.1038/s41598-025-19588-1
001049047 0247_ $$2datacite_doi$$a10.34734/FZJ-2025-05142
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001049047 1001_ $$0P:(DE-HGF)0$$adeSteiguer, Abby J$$b0
001049047 245__ $$aSalivary DNA methylation and pubertal development in adolescents.
001049047 260__ $$a[London]$$bSpringer Nature$$c2025
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001049047 520__ $$aIndividuals differ in when and how quickly they experience puberty, and these differences in pubertal development are associated with lifelong health and mortality. We conducted sex-specific epigenome-wide association analyses of salivary DNA-methylation (DNAm) samples from ~ 3500 adolescents and identified 373 DNAm sites significantly associated with pubertal age, pace of pubertal development, and/or onset of early puberty by age 9. These DNAm signals converged with results from previous genomic and transcriptomic studies of puberty and with pan-mammalian epigenomic studies of age. Genomic annotations and trait enrichment results implicate child maltreatment and toxicant exposures as relevant for puberty. We developed a novel DNAm biomarker of pubertal age that was consistently associated with earlier age at menarche across three adolescent cohorts. Saliva DNAm is sensitive to signatures of pubertal development and suggests molecular links between reproductive maturation and both embryonic development and biological aging across species.
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001049047 650_7 $$2Other$$aAging
001049047 650_7 $$2Other$$aDNA-methylation
001049047 650_7 $$2Other$$aEpigenetics
001049047 650_7 $$2Other$$aMenarche
001049047 650_7 $$2Other$$aPuberty
001049047 650_7 $$2NLM Chemicals$$aBiomarkers
001049047 650_2 $$2MeSH$$aHumans
001049047 650_2 $$2MeSH$$aDNA Methylation
001049047 650_2 $$2MeSH$$aFemale
001049047 650_2 $$2MeSH$$aAdolescent
001049047 650_2 $$2MeSH$$aMale
001049047 650_2 $$2MeSH$$aSaliva: metabolism
001049047 650_2 $$2MeSH$$aPuberty: genetics
001049047 650_2 $$2MeSH$$aChild
001049047 650_2 $$2MeSH$$aGenome-Wide Association Study
001049047 650_2 $$2MeSH$$aEpigenesis, Genetic
001049047 650_2 $$2MeSH$$aMenarche: genetics
001049047 650_2 $$2MeSH$$aBiomarkers
001049047 7001_ $$0P:(DE-HGF)0$$aSmith, Trey$$b1
001049047 7001_ $$0P:(DE-HGF)0$$aGoode, Joshua A$$b2
001049047 7001_ $$0P:(DE-HGF)0$$aWillems, Yayouk E$$b3
001049047 7001_ $$0P:(DE-HGF)0$$aSchowe, Alicia M$$b4
001049047 7001_ $$0P:(DE-HGF)0$$aCzamara, Darina$$b5
001049047 7001_ $$0P:(DE-HGF)0$$aMönkediek, Bastian$$b6
001049047 7001_ $$0P:(DE-HGF)0$$aPahnke, Charlotte K L$$b7
001049047 7001_ $$0P:(DE-Juel1)186755$$aForstner, Andreas J$$b8
001049047 7001_ $$0P:(DE-HGF)0$$aBinder, Elisabeth B$$b9
001049047 7001_ $$0P:(DE-HGF)0$$aSchneper, Lisa$$b10
001049047 7001_ $$0P:(DE-HGF)0$$aNotterman, Daniel A$$b11
001049047 7001_ $$0P:(DE-HGF)0$$aTucker-Drob, Elliot M$$b12
001049047 7001_ $$0P:(DE-HGF)0$$aRaffington, Laurel$$b13
001049047 7001_ $$0P:(DE-HGF)0$$aMitchell, Colter$$b14
001049047 7001_ $$0P:(DE-HGF)0$$aHarden, K Paige$$b15$$eCorresponding author
001049047 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-19588-1$$gVol. 15, no. 1, p. 35970$$n1$$p35970$$tScientific reports$$v15$$x2045-2322$$y2025
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