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@ARTICLE{deSteiguer:1049047,
      author       = {deSteiguer, Abby J and Smith, Trey and Goode, Joshua A and
                      Willems, Yayouk E and Schowe, Alicia M and Czamara, Darina
                      and Mönkediek, Bastian and Pahnke, Charlotte K L and
                      Forstner, Andreas J and Binder, Elisabeth B and Schneper,
                      Lisa and Notterman, Daniel A and Tucker-Drob, Elliot M and
                      Raffington, Laurel and Mitchell, Colter and Harden, K Paige},
      title        = {{S}alivary {DNA} methylation and pubertal development in
                      adolescents.},
      journal      = {Scientific reports},
      volume       = {15},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {FZJ-2025-05142},
      pages        = {35970},
      year         = {2025},
      abstract     = {Individuals differ in when and how quickly they experience
                      puberty, and these differences in pubertal development are
                      associated with lifelong health and mortality. We conducted
                      sex-specific epigenome-wide association analyses of salivary
                      DNA-methylation (DNAm) samples from ~ 3500 adolescents and
                      identified 373 DNAm sites significantly associated with
                      pubertal age, pace of pubertal development, and/or onset of
                      early puberty by age 9. These DNAm signals converged with
                      results from previous genomic and transcriptomic studies of
                      puberty and with pan-mammalian epigenomic studies of age.
                      Genomic annotations and trait enrichment results implicate
                      child maltreatment and toxicant exposures as relevant for
                      puberty. We developed a novel DNAm biomarker of pubertal age
                      that was consistently associated with earlier age at
                      menarche across three adolescent cohorts. Saliva DNAm is
                      sensitive to signatures of pubertal development and suggests
                      molecular links between reproductive maturation and both
                      embryonic development and biological aging across species.},
      keywords     = {Humans / DNA Methylation / Female / Adolescent / Male /
                      Saliva: metabolism / Puberty: genetics / Child / Genome-Wide
                      Association Study / Epigenesis, Genetic / Menarche: genetics
                      / Biomarkers / Aging (Other) / DNA-methylation (Other) /
                      Epigenetics (Other) / Menarche (Other) / Puberty (Other) /
                      Biomarkers (NLM Chemicals)},
      cin          = {INM-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1038/s41598-025-19588-1},
      url          = {https://juser.fz-juelich.de/record/1049047},
}