Hauptseite > Publikationsdatenbank > Salivary DNA methylation and pubertal development in adolescents. > print

001     1049047
005     20251211202156.0
024 7 _ |a 10.1038/s41598-025-19588-1
|2 doi
024 7 _ |a 10.34734/FZJ-2025-05142
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082 _ _ |a 600
100 1 _ |a deSteiguer, Abby J
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245 _ _ |a Salivary DNA methylation and pubertal development in adolescents.
260 _ _ |a [London]
|c 2025
|b Springer Nature
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520 _ _ |a Individuals differ in when and how quickly they experience puberty, and these differences in pubertal development are associated with lifelong health and mortality. We conducted sex-specific epigenome-wide association analyses of salivary DNA-methylation (DNAm) samples from ~ 3500 adolescents and identified 373 DNAm sites significantly associated with pubertal age, pace of pubertal development, and/or onset of early puberty by age 9. These DNAm signals converged with results from previous genomic and transcriptomic studies of puberty and with pan-mammalian epigenomic studies of age. Genomic annotations and trait enrichment results implicate child maltreatment and toxicant exposures as relevant for puberty. We developed a novel DNAm biomarker of pubertal age that was consistently associated with earlier age at menarche across three adolescent cohorts. Saliva DNAm is sensitive to signatures of pubertal development and suggests molecular links between reproductive maturation and both embryonic development and biological aging across species.
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650 _ 7 |a Aging
|2 Other
650 _ 7 |a DNA-methylation
|2 Other
650 _ 7 |a Epigenetics
|2 Other
650 _ 7 |a Menarche
|2 Other
650 _ 7 |a Puberty
|2 Other
650 _ 7 |a Biomarkers
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a DNA Methylation
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Adolescent
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Saliva: metabolism
|2 MeSH
650 _ 2 |a Puberty: genetics
|2 MeSH
650 _ 2 |a Child
|2 MeSH
650 _ 2 |a Genome-Wide Association Study
|2 MeSH
650 _ 2 |a Epigenesis, Genetic
|2 MeSH
650 _ 2 |a Menarche: genetics
|2 MeSH
650 _ 2 |a Biomarkers
|2 MeSH
700 1 _ |a Smith, Trey
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700 1 _ |a Goode, Joshua A
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700 1 _ |a Willems, Yayouk E
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700 1 _ |a Schowe, Alicia M
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700 1 _ |a Czamara, Darina
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700 1 _ |a Mönkediek, Bastian
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700 1 _ |a Pahnke, Charlotte K L
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700 1 _ |a Forstner, Andreas J
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700 1 _ |a Binder, Elisabeth B
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700 1 _ |a Schneper, Lisa
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700 1 _ |a Notterman, Daniel A
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700 1 _ |a Tucker-Drob, Elliot M
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700 1 _ |a Raffington, Laurel
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700 1 _ |a Mitchell, Colter
|0 P:(DE-HGF)0
|b 14
700 1 _ |a Harden, K Paige
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|b 15
|e Corresponding author
773 _ _ |a 10.1038/s41598-025-19588-1
|g Vol. 15, no. 1, p. 35970
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|t Scientific reports
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856 4 _ |u https://juser.fz-juelich.de/record/1049047/files/DeSteiguer_etal_ScientificReports_2025.pdf
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