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@ARTICLE{Vieregge:1049996,
      author       = {Vieregge, Magdalena and Kuzkina, Anastasia and Janzen,
                      Annette and Oertel, Wolfgang H. and Sommerauer, Michael and
                      Volkmann, Jens and Doppler, Kathrin},
      title        = {{D}ermal {A}lpha‐{S}ynuclein {A}ggregation in {S}eed
                      {A}mplification {A}ssays for {P}arkinson's {D}isease
                      {S}ubtype {D}ifferentiation},
      journal      = {European journal of neurology},
      volume       = {32},
      number       = {12},
      issn         = {1351-5101},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2025-05710},
      pages        = {e70453},
      year         = {2025},
      note         = {This work was supported by German Federal Ministry of
                      Education and Research (BMBF). We thank Andrea
                      Sauer-Weckertand Antonia Kohl for expert
                      technicalassistance. Kathrin Doppler is supported by grants
                      from theInterdisciplinary Center of Clinical Research of the
                      University HospitalWürzburg and by the German Research
                      Foundation as a member of theClinical Research Unit
                      ResolvePain. Brain lysates were kindly providedby Camelia
                      Monoranu. Michael Sommerauer receives funding from
                      theprogram “Netzwerke 2021”, an initiative of the
                      Ministry of Culture andScience of the State of
                      Northrhine-Westphalia,and from the FederalMinistry of
                      Education and Research (BMBF) within the frameworkof the
                      funding programme ACCENT (funding code 01EO2107). OpenAccess
                      funding enabled and organized by Projekt DEAL.},
      abstract     = {Skin biopsies and seed amplification assays (SAA) provide a
                      sensitive and potentially quantitative method to detect
                      alpha‐synuclein (a‐syn) aggregation in peripheral nerve
                      fibers in Parkinson's disease (PD). Relating to the
                      previously published hypothesis that PD may either originate
                      in the peripheral (body‐first) or central (brain‐first)
                      nervous system, we investigated whether patients with
                      clinical features that have been reported to be associated
                      with a suspected body‐first subtype of PD exhibit higher
                      levels of a‐syn aggregation in dermal nerve fibers
                      compared to those without these features. Patients with
                      isolated REM sleep behavior disorder (iRBD) representing a
                      suspected premotor stage of body‐first PD were studied in
                      comparison to the PD cohort.MethodsPatients were categorized
                      on the basis of clinical features, and SAA parameters such
                      as lag time, number of positive curves, and titers were
                      analyzed and correlated with clinical
                      features.ResultsAlthough patients with clinical features of
                      suspected body‐first PD showed slightly higher titers,
                      significant differences were mainly observed between iRBD
                      patients and PD patients.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1111/ene.70453},
      url          = {https://juser.fz-juelich.de/record/1049996},
}