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@ARTICLE{Schller:1050001,
      author       = {Schüller, Thomas and Mengotti, Paola and Zabicki, Adam and
                      Huys, Daniel and Barbe, Michael T and Fink, Gereon R and
                      Visser-Vandewalle, Veerle and Vossel, Simone and Baldermann,
                      Juan Carlos},
      title        = {{A}lterations of sensorimotor predictive processes and
                      their electrophysiological signatures in {T}ourette
                      syndrome},
      journal      = {Brain communications},
      volume       = {7},
      number       = {6},
      issn         = {2632-1297},
      address      = {[Oxford]},
      publisher    = {Oxford University Press},
      reportid     = {FZJ-2025-05715},
      pages        = {fcaf458},
      year         = {2025},
      note         = {This work was funded by the German Research Foundation (SFB
                      1451 – ID 431549029). J.C.B. is funded by the Else
                      Kroner-Fresenius Stiftung $(2022_EKES.23).$},
      abstract     = {People with Tourette syndrome exhibit excessive motor
                      actions known as tics. An aversive sensation called the
                      premonitory urge often precedes these tics, leading to the
                      conceptualization of Tourette syndrome as a sensorimotor
                      disorder. In typical individuals, motor actions adapt
                      flexibly to changes in the predictability of sensory cues.
                      However, it remains unclear whether such sensorimotor
                      predictions are altered in Tourette syndrome and, if so,
                      which neural processes might underlie these changes. This
                      study examined 30 individuals with Tourette syndrome and 30
                      control participants while recording EEG. Participants
                      performed a motor cueing version of the Posner task,
                      requiring behavioural adjustments to varying levels of cue
                      predictability. Notably, while control participants
                      exhibited the expected interaction between validity and cue
                      predictability on motor responses, this effect was absent in
                      individuals with Tourette syndrome. Neural signatures of
                      flexible predictability-dependent processing were
                      characterized by applying a Bayesian observer model to
                      estimate trial-wise subjective beliefs about cue
                      predictability from response speed and using these
                      model-derived cue predictability estimates in single-trial
                      regression analyses with EEG data. Our findings revealed
                      that model-derived cue predictability modulated P3a
                      amplitude, P3b onset and P3b amplitude differentially.
                      Importantly, P3b amplitude modulations reflected beliefs
                      about cue predictability, which were diminished in
                      participants with Tourette syndrome. Overall, our results
                      indicate that individuals with Tourette syndrome exhibit
                      abnormal behavioural adaptation to the changing
                      predictability of motor cues, suggesting an impaired
                      processing of sensorimotor predictions. At the neural level,
                      this is reflected by impaired activity associated with
                      updating stimulus–response associations.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1093/braincomms/fcaf458},
      url          = {https://juser.fz-juelich.de/record/1050001},
}