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001050018 1001_ $$aTscherpel, Caroline$$b0
001050018 245__ $$aEvoked slow oscillations and dynamic network reorganization after stroke
001050018 260__ $$a[Oxford]$$bOxford University Press$$c2025
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001050018 500__ $$aG.R.F., C.G. and C.T. are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project-ID 431549029—SFB 1451 (projects B03, B06, C05 and Z03).
001050018 520__ $$aA focal ischemic lesion is thought to alter neuronal activity beyond the area of structural damage, thereby interfering with the whole network architecture. Here, we used a combination of transcranial magnetic stimulation and electroencephalography in conjunction with dynamic connectivity analyses and graph theory to study alterations and reorganization of cortical connectivity in a cohort of 41 patients longitudinally after stroke. We found a link between an increase in low-frequency coupling in the delta band and alterations in neural information processing in the first weeks after stroke and their relevance for motor outcome >3 months later. We demonstrated that stroke enhances slow activity and delta coupling between frontocentral and parietal regions. In addition, we observed a loss of the physiological network architecture with a decrease in small-worldness and modularity in the delta frequency, implying that a focal ischemic lesion interferes with both cortical information integration and functional segregation within the first weeks after stroke. While we found a link between bifrontal coupling in the alpha spectrum and the degree of the motor deficit in the early post-acute phase, the amount of small-worldness disruption early after stroke indicated the motor outcome in the follow-up session. In contrast, recovery of motor function and cortical reorganization after >3 months post-stroke were paralleled by the normalization of increased low-frequency coupling and a reinstatement of the complex network structure featuring a modular and small-world topology.Keywords: diaschisis; modularity; neuroplasticity; randomness; small-worldness.
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001050018 536__ $$0G:(GEPRIS)431549029$$aDFG project G:(GEPRIS)431549029 - SFB 1451: Schlüsselmechanismen normaler und krankheitsbedingt gestörter motorischer Kontrolle (431549029)$$c431549029$$x1
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001050018 7001_ $$0P:(DE-Juel1)201297$$aMustin, Maike$$b1
001050018 7001_ $$0P:(DE-Juel1)164124$$aRosjat, Nils$$b2
001050018 7001_ $$0P:(DE-HGF)0$$aMais, Lea-Theresa$$b3
001050018 7001_ $$00000-0001-8372-3615$$aZiemann, Ulf$$b4
001050018 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R$$b5$$ufzj
001050018 7001_ $$0P:(DE-Juel1)162297$$aDaun, Silvia$$b6$$ufzj
001050018 7001_ $$0P:(DE-Juel1)161406$$aGrefkes, Christian$$b7$$eCorresponding author
001050018 773__ $$0PERI:(DE-600)3020013-1$$a10.1093/braincomms/fcaf391$$gVol. 7, no. 6, p. fcaf391$$n6$$pfcaf391$$tBrain communications$$v7$$x2632-1297$$y2025
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