TY  - JOUR
AU  - Tscherpel, Caroline
AU  - Mustin, Maike
AU  - Rosjat, Nils
AU  - Mais, Lea-Theresa
AU  - Ziemann, Ulf
AU  - Fink, Gereon R
AU  - Daun, Silvia
AU  - Grefkes, Christian
TI  - Evoked slow oscillations and dynamic network reorganization after stroke
JO  - Brain communications
VL  - 7
IS  - 6
SN  - 2632-1297
CY  - [Oxford]
PB  - Oxford University Press
M1  - FZJ-2025-05732
SP  - fcaf391
PY  - 2025
N1  - G.R.F., C.G. and C.T. are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)—Project-ID 431549029—SFB 1451 (projects B03, B06, C05 and Z03).
AB  - A focal ischemic lesion is thought to alter neuronal activity beyond the area of structural damage, thereby interfering with the whole network architecture. Here, we used a combination of transcranial magnetic stimulation and electroencephalography in conjunction with dynamic connectivity analyses and graph theory to study alterations and reorganization of cortical connectivity in a cohort of 41 patients longitudinally after stroke. We found a link between an increase in low-frequency coupling in the delta band and alterations in neural information processing in the first weeks after stroke and their relevance for motor outcome >3 months later. We demonstrated that stroke enhances slow activity and delta coupling between frontocentral and parietal regions. In addition, we observed a loss of the physiological network architecture with a decrease in small-worldness and modularity in the delta frequency, implying that a focal ischemic lesion interferes with both cortical information integration and functional segregation within the first weeks after stroke. While we found a link between bifrontal coupling in the alpha spectrum and the degree of the motor deficit in the early post-acute phase, the amount of small-worldness disruption early after stroke indicated the motor outcome in the follow-up session. In contrast, recovery of motor function and cortical reorganization after >3 months post-stroke were paralleled by the normalization of increased low-frequency coupling and a reinstatement of the complex network structure featuring a modular and small-world topology.Keywords: diaschisis; modularity; neuroplasticity; randomness; small-worldness.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1093/braincomms/fcaf391
UR  - https://juser.fz-juelich.de/record/1050018
ER  -