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@ARTICLE{Kuzu:1050027,
      author       = {Kuzu, Taylan D. and Brinkmann, Elena and Bonkhoff, Anna K.
                      and Wunderle, Veronika and Bischof, Gérard N. and Giehl,
                      Kathrin and Schmieschek, Maximilian H. T. and Onur, Oezguer
                      A. and Jessen, Frank and Fink, Gereon R. and Drzezga,
                      Alexander and Weiss-Blankenhorn, Peter},
      title        = {{A}praxic deficits in {A}lzheimer’s disease are
                      associated with altered dynamic connectivity in
                      praxis-related networks},
      journal      = {Neurobiology of aging},
      volume       = {157},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2025-05741},
      pages        = {36 - 47},
      year         = {2026},
      note         = {THe DFG funded this study. Project ID 431549029 SFB 1451
                      and Project ID DR445/9-1.Gereon R. Fink and Oezguer A. Onur
                      were supported by the Marga and Walter Boll-Foundation.},
      abstract     = {Apraxia is a common symptom in Alzheimer's disease (AD)
                      that reduces autonomy and quality of life. However, the
                      neural basis underlying apraxia in AD, for example,
                      reflected by functional connectivity (FC) alterations,
                      remains unexplored. We investigated static and dynamic FC
                      using resting-state functional imaging in 14 patients with
                      biomarker-confirmed AD pathology and 14 matched healthy
                      participants. FC was estimated as average (static) and
                      short-term (dynamic) connectivity strengths between motor-
                      and praxis-related functional networks. Recurring
                      connectivity patterns were clustered into dynamic states to
                      compute temporal connectivity measures. Connectivity
                      measures were used for correlations with apraxic deficits.
                      In AD patients, static connectivity between visual and
                      inferior parietal networks correlated with apraxic imitation
                      (r = 0.762, PFDR = 0.043) and arm/hand gesture deficits (r =
                      0.848, PFDR = 0.020), while dynamic connectivity between
                      these networks correlated with apraxic imitation deficits (r
                      = 0.851, PFDR = 0.020). Dynamic FC analysis revealed a
                      segregated and integrated state. AD patients spent more time
                      overall (fraction time, PFDR < 0.001) and remained longer
                      without switching (dwell time, PFDR = 0.004) in the
                      segregated state. Both fraction (ρ = -0.858, PFDR = 0.015)
                      and dwell time (ρ = -0.914, PFDR = 0.003) correlated with
                      apraxic imitation deficits. Connectivity strengths between
                      visual and inferior parietal networks and fraction time in
                      the segregated state predicted apraxic imitation deficits
                      (adjusted R2 = 0.782, P < 0.001). We conclude that apraxia
                      in AD patients is associated with altered FC in
                      praxis-related networks, suggesting FC as a potential
                      clinical indicator for predicting motor-cognitive
                      deficits.Keywords: Aging; Alzheimer’s disease; Cologne
                      apraxia screening (KAS); Functional magnetic resonance
                      imaging; Motor system; Praxis; Resting-state.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / DFG project G:(GEPRIS)431549029 - SFB 1451:
                      Schlüsselmechanismen normaler und krankheitsbedingt
                      gestörter motorischer Kontrolle (431549029)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(GEPRIS)431549029},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.neurobiolaging.2025.09.007},
      url          = {https://juser.fz-juelich.de/record/1050027},
}