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@INPROCEEDINGS{Zimmermann:1050138,
author = {Zimmermann, Olav and Meinke, Jan and Mohanty, Sandipan},
title = {{A}ll-{A}tom {MCMC} {S}imulation of {P}rotein {F}olding
with {P}ro{FAS}i},
reportid = {FZJ-2025-05842},
year = {2025},
abstract = {We will introduce ProFASi, a versatile open source software
for simulation of biomolecular structure formation such as
protein folding or peptide aggregation. An all-atom
representation of the protein molecules with implicit
solvent is used in ProFASi. The software features efficient
implementations of several Monte Carlo methods that update
the torsional degrees of freedom, as well as global
translation and rotation of individual molecules. ProFASi
has been used to perform unbiased simulations of protein
folding of several small molecules including the designed 92
aa protein Top7 as well as simulation of peptide aggregation
up to 512 hexapeptides. Several use cases and options for
plugin development are presented.},
month = {Mar},
date = {2025-03-07},
organization = {Workshop on Computer Simulation and
Theory of Macromolecules, Hünfeld
(Germany), 7 Mar 2025 - 8 Mar 2025},
subtyp = {Outreach},
cin = {JSC},
cid = {I:(DE-Juel1)JSC-20090406},
pnm = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
(SDLs) and Research Groups (POF4-511)},
pid = {G:(DE-HGF)POF4-5111},
typ = {PUB:(DE-HGF)24},
doi = {10.34734/FZJ-2025-05842},
url = {https://juser.fz-juelich.de/record/1050138},
}