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@ARTICLE{Vercellino:1051591,
      author       = {Vercellino, Irene and Sazanov, Leonid A.},
      title        = {{A}uthor {C}orrection: {SCAF}1 drives the compositional
                      diversity of mammalian respirasomes},
      journal      = {Nature structural $\&$ molecular biology},
      volume       = {32},
      number       = {11},
      issn         = {1545-9993},
      address      = {London [u.a.]},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2026-00517},
      pages        = {2371 - 2371},
      year         = {2025},
      abstract     = {Supercomplexes of the respiratory chain are established
                      constituents of the oxidative phosphorylation system, but
                      their role in mammalian metabolism has been hotly debated.
                      Although recent studies have shown that different
                      tissues/organs are equipped with specific sets of
                      supercomplexes, depending on their metabolic needs, the
                      notion that supercomplexes have a role in the regulation of
                      metabolism has been challenged. However, irrespective of the
                      mechanistic conclusions, the composition of various high
                      molecular weight supercomplexes remains uncertain. Here,
                      using cryogenic electron microscopy, we demonstrate that
                      mammalian (mouse) tissues contain three defined types of
                      ‘respirasome’, supercomplexes made of CI, CIII2 and CIV.
                      The stoichiometry and position of CIV differs in the three
                      respirasomes, of which only one contains the
                      supercomplex-associated factor SCAF1, whose involvement in
                      respirasome formation has long been contended. Our
                      structures confirm that the ‘canonical’ respirasome (the
                      C-respirasome, CICIII2CIV) does not contain SCAF1, which is
                      instead associated to a different respirasome (the
                      CS-respirasome), containing a second copy of CIV. We also
                      identify an alternative respirasome (A-respirasome), with
                      CIV bound to the ‘back’ of CI, instead of the ‘toe’.
                      This structural characterization of mouse mitochondrial
                      supercomplexes allows us to hypothesize a mechanistic basis
                      for their specific role in different metabolic conditions.},
      cin          = {ER-C-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ER-C-3-20170113},
      pnm          = {5352 - Understanding the Functionality of Soft Matter and
                      Biomolecular Systems (POF4-535) / 5241 - Molecular
                      Information Processing in Cellular Systems (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5352 / G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {41193677},
      UT           = {WOS:001609035000001},
      doi          = {10.1038/s41594-025-01721-3},
      url          = {https://juser.fz-juelich.de/record/1051591},
}