001052091 001__ 1052091
001052091 005__ 20260120203627.0
001052091 0247_ $$2doi$$a10.1002/1873-3468.70153
001052091 0247_ $$2ISSN$$a0014-5793
001052091 0247_ $$2ISSN$$a1873-3468
001052091 0247_ $$2datacite_doi$$a10.34734/FZJ-2026-00756
001052091 037__ $$aFZJ-2026-00756
001052091 082__ $$a610
001052091 1001_ $$0P:(DE-Juel1)192261$$aLemke, Moritz$$b0$$ufzj
001052091 245__ $$aStructural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment
001052091 260__ $$aChichester$$bWiley$$c2025
001052091 3367_ $$2DRIVER$$aarticle
001052091 3367_ $$2DataCite$$aOutput Types/Journal article
001052091 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1768922723_2757
001052091 3367_ $$2BibTeX$$aARTICLE
001052091 3367_ $$2ORCID$$aJOURNAL_ARTICLE
001052091 3367_ $$00$$2EndNote$$aJournal Article
001052091 520__ $$aEthylene (C2H4) regulates plant processes, such as germination, fruit ripening, and stress responses, impacting nutrition and food quality. The membrane-bound receptor ETR1 from Arabidopsis thaliana is a model for ethylene signaling, but both full-length and the soluble cytoplasmic domain have resisted crystallization. We present high-resolution NMR spectra of full-length ETR1 reconstituted in lipid nanodiscs, overcoming limitations and enhancing sample uniformity. ETR1 shows high internal dynamics with regions decoupled from the transmembrane domain, possibly explaining past crystallization failures and reflecting functional flexibility. Introduction of Cu(I), an essential cofactor for ethylene binding, stiffened receptor dynamics, suggesting a stabilizing role in signal transmission. This work demonstrates nanodisc-based strategies as powerful tools for resolving membrane protein structures in plant signaling.
001052091 536__ $$0G:(DE-HGF)POF4-5241$$a5241 - Molecular Information Processing in Cellular Systems (POF4-524)$$cPOF4-524$$fPOF IV$$x0
001052091 588__ $$aDataset connected to CrossRef, Journals: juser.fz-juelich.de
001052091 7001_ $$0P:(DE-Juel1)180657$$aLakomek, Nils Alexander$$b1$$eCorresponding author$$ufzj
001052091 7001_ $$00000-0002-1806-9861$$aGroth, Georg$$b2$$eCorresponding author
001052091 773__ $$0PERI:(DE-600)1460391-3$$a10.1002/1873-3468.70153$$gVol. 599, no. 22, p. 3381 - 3391$$n22$$p3381 - 3391$$tFEBS letters$$v599$$x0014-5793$$y2025
001052091 8564_ $$uhttps://juser.fz-juelich.de/record/1052091/files/FEBS%20Letters%20-%202025%20-%20Lemke%20-%20Structural%20dynamics%20of%20the%20plant%20hormone%20receptor%20ETR1%20in%20a%20native%E2%80%90like%20membrane%20environment.pdf$$yOpenAccess
001052091 909CO $$ooai:juser.fz-juelich.de:1052091$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
001052091 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)192261$$aForschungszentrum Jülich$$b0$$kFZJ
001052091 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)180657$$aForschungszentrum Jülich$$b1$$kFZJ
001052091 9131_ $$0G:(DE-HGF)POF4-524$$1G:(DE-HGF)POF4-520$$2G:(DE-HGF)POF4-500$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF4-5241$$aDE-HGF$$bKey Technologies$$lNatural, Artificial and Cognitive Information Processing$$vMolecular and Cellular Information Processing$$x0
001052091 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bFEBS LETT : 2022$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2024-12-19$$wger
001052091 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
001052091 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2024-12-19
001052091 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2024-12-19
001052091 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
001052091 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2024-12-19
001052091 920__ $$lyes
001052091 9201_ $$0I:(DE-Juel1)IBI-7-20200312$$kIBI-7$$lStrukturbiochemie$$x0
001052091 980__ $$ajournal
001052091 980__ $$aVDB
001052091 980__ $$aUNRESTRICTED
001052091 980__ $$aI:(DE-Juel1)IBI-7-20200312
001052091 9801_ $$aFullTexts