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@ARTICLE{Lemke:1052091,
      author       = {Lemke, Moritz and Lakomek, Nils Alexander and Groth, Georg},
      title        = {{S}tructural dynamics of the plant hormone receptor {ETR}1
                      in a native‐like membrane environment},
      journal      = {FEBS letters},
      volume       = {599},
      number       = {22},
      issn         = {0014-5793},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {FZJ-2026-00756},
      pages        = {3381 - 3391},
      year         = {2025},
      abstract     = {Ethylene (C2H4) regulates plant processes, such as
                      germination, fruit ripening, and stress responses, impacting
                      nutrition and food quality. The membrane-bound receptor ETR1
                      from Arabidopsis thaliana is a model for ethylene signaling,
                      but both full-length and the soluble cytoplasmic domain have
                      resisted crystallization. We present high-resolution NMR
                      spectra of full-length ETR1 reconstituted in lipid
                      nanodiscs, overcoming limitations and enhancing sample
                      uniformity. ETR1 shows high internal dynamics with regions
                      decoupled from the transmembrane domain, possibly explaining
                      past crystallization failures and reflecting functional
                      flexibility. Introduction of Cu(I), an essential cofactor
                      for ethylene binding, stiffened receptor dynamics,
                      suggesting a stabilizing role in signal transmission. This
                      work demonstrates nanodisc-based strategies as powerful
                      tools for resolving membrane protein structures in plant
                      signaling.},
      cin          = {IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5241 - Molecular Information Processing in Cellular Systems
                      (POF4-524)},
      pid          = {G:(DE-HGF)POF4-5241},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1002/1873-3468.70153},
      url          = {https://juser.fz-juelich.de/record/1052091},
}