% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Hater:1052109,
      author       = {Hater, Thorsten and Courson, Juliette and Lu, Han and Diaz,
                      Sandra and Manos, Thanos},
      title        = {{A}rbor-{TVB}: {A} {N}ovel {M}ulti-{S}cale
                      {C}o-{S}imulation {F}ramework with a {C}ase {S}tudy on
                      {N}eural-{L}evel {S}eizure {G}eneration},
      journal      = {Frontiers in computational neuroscience},
      volume       = {19},
      issn         = {1662-5188},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2026-00762},
      pages        = {1731161},
      year         = {2026},
      abstract     = {Computational neuroscience has traditionally focused on
                      isolated scales, limiting understanding of brain function
                      across multiple levels. While microscopic models capture
                      biophysical details of neurons, macroscopic models describe
                      large-scale network dynamics. Integrating these scales,
                      however, remains a significant challenge. In this study, we
                      present a novel co-simulation framework that bridges these
                      levels by integrating the neural simulator Arbor with The
                      Virtual Brain (TVB) platform. Arbor enables detailed
                      simulations from single-compartment neurons to populations
                      of such cells, while TVB models whole-brain dynamics based
                      on anatomical features and the mean neural activity of a
                      brain region. By linking these simulators for the first
                      time, we provide an example of how to model and investigate
                      the onset of seizures in specific areas and their
                      propagation to the whole brain. This framework employs an
                      MPI intercommunicator for real-time bidirectional
                      interaction, translating between discrete spikes from Arbor
                      and continuous TVB activity. Its fully modular design
                      enables independent model selection for each scale,
                      requiring minimal effort to translate activity across
                      simulators. The novel Arbor-TVB co-simulator allows
                      replacement of TVB nodes with biologically realistic neuron
                      populations, offering insights into seizure propagation and
                      potential intervention strategies. The integration of Arbor
                      and TVB marks a significant advancement in multi-scale
                      modeling, providing a comprehensive computational framework
                      for studying neural disorders and optimizing treatments.},
      cin          = {JSC / CASA},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)CASA-20230315},
      pnm          = {5111 - Domain-Specific Simulation $\&$ Data Life Cycle Labs
                      (SDLs) and Research Groups (POF4-511) / SLNS - SimLab
                      Neuroscience (Helmholtz-SLNS) / JL SMHB - Joint Lab
                      Supercomputing and Modeling for the Human Brain (JL
                      SMHB-2021-2027) / EBRAINS 2.0 - EBRAINS 2.0: A Research
                      Infrastructure to Advance Neuroscience and Brain Health
                      (101147319) / DFG project G:(GEPRIS)491111487 -
                      Open-Access-Publikationskosten / 2025 - 2027 /
                      Forschungszentrum Jülich (OAPKFZJ) (491111487)},
      pid          = {G:(DE-HGF)POF4-5111 / G:(DE-Juel1)Helmholtz-SLNS /
                      G:(DE-Juel1)JL SMHB-2021-2027 / G:(EU-Grant)101147319 /
                      G:(GEPRIS)491111487},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.3389/fncom.2025.1731161},
      url          = {https://juser.fz-juelich.de/record/1052109},
}