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@ARTICLE{Baumert:1052211,
      author       = {Baumert, Brigitta G. and P. M. Jaspers, Jaap and Keil, Vera
                      C. and Galldiks, Norbert and Izycka-Swieszewska, Ewa and
                      Timmermann, Beate and Grosu, Anca L. and Minniti, Giuseppe
                      and Ricardi, Umberto and Dhermain, Frédéric and Weber,
                      Damien C. and van den Bent, Martin and Rudà, Roberta and
                      Niyazi, Maximilian and Erridge, Sara},
      title        = {{ESTRO}-{EANO} guideline on target delineation and
                      radiotherapy for {IDH}-mutant {WHO} {CNS} grade 2 and 3
                      diffuse glioma},
      journal      = {Radiotherapy and oncology},
      volume       = {202},
      issn         = {0167-8140},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2026-00839},
      pages        = {110594 -},
      year         = {2025},
      note         = {No funding has been received for the development of these
                      guidelines.},
      abstract     = {Purpose: This guideline will discuss radiotherapeutic
                      management of IDH-mutant grade 2 and grade 3 diffuse glioma,
                      using the latest 2021 WHO (5th) classification of brain
                      tumours focusing on: imaging modalities, tumour volume
                      delineation, irradiation dose and fractionation.Methods: The
                      ESTRO Guidelines Committee, CNS subgroup, nominated 15
                      European experts who identified questions for this
                      guideline. Four working groups were established addressing
                      specific questions concerning imaging, target volume
                      delineation, radiation techniques and fractionation. A
                      literature search was performed, and available literature
                      was discussed. A modified two-step Delphi process was used
                      with majority voting resulted in a decision or highlighting
                      areas of uncertainty.Results: Key issues identified and
                      discussed included imaging needed to define target
                      definition, target delineation and the size of margins, and
                      technical aspects of treatment including different planning
                      techniques such as proton therapy.Conclusions: The GTV
                      should include any residual tumour volume after surgery, as
                      well as the resection cavity. Enhancing lesions on T1
                      imaging should be included if they are indicative of
                      residual tumour. In grade 2 tumours, T2/FLAIR abnormalities
                      should be included in the GTV. In grade 3 tumours, T2/FLAIR
                      abnormalities should also be included, except areas that are
                      considered to be oedema which should be omitted from the
                      GTV. A GTV to CTV expansion of 10 mm is recommended in grade
                      2 tumours and 15 mm in grade 3 tumours. A treatment dose of
                      50.4 Gy in 28 fractions is recommended in grade 2 tumours
                      and 59.4 Gy in 33 fractions in grade 3 tumours. Radiation
                      techniques with IMRT are the preferred approach.Keywords:
                      Anaplastic glioma; Delineation; IDH-mutant diffuse glioma;
                      Low grade glioma; Radiotherapy; Target volume.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1016/j.radonc.2024.110594},
      url          = {https://juser.fz-juelich.de/record/1052211},
}