TY  - JOUR
AU  - Royer, Jessica
AU  - Paquola, Casey
AU  - Rodriguez-Cruces, Raul
AU  - Auer, Hans
AU  - Ngo, Alexander
AU  - Sahlas, Ella
AU  - Arafat, Thaera
AU  - Abdallah, Chifaou
AU  - Mansilla de Latorre, Daniel
AU  - Pana, Raluca
AU  - Hall, Jeffrey
AU  - Leech, Robert
AU  - Smallwood, Jonathan
AU  - Frauscher, Birgit
AU  - Bernhardt, Boris C.
TI  - Human cortical dynamics reflect graded contributions of local geometry and network topography
JO  - Nature Communications
VL  - 17
SN  - 2041-1723
CY  - [London]
PB  - Springer Nature
M1  - FZJ-2026-00879
SP  - 1002
PY  - 2026
AB  - The brain is a physically embedded and heavily interconnected system that expresses neural rhythms across multiple time scales. While these dynamics result from the complex interplay of local and inter-regional factors, the relative contribution of such mechanisms across the cortex remains unclear. Our study explores geometric, microstructural, and connectome-level constraints on cortex-wide neural activity. We leverage intracranial electroencephalography recordings to derive a coordinate system of human cortical dynamics. Using multimodal neuroimaging, we could then demonstrate that these patterns are largely explainable by geometric properties indexed by inter-regional distance. However, dynamics in transmodal association regions are additionally explainable by incorporation of inter-regional microstructural similarity and connectivity information. Our findings are generally consistent when cross-referencing electroencephalography and imaging data from large-scale atlases and when using data obtained in the same individuals, suggesting subject-specificity and population-level generalizability. Together, our results suggest that the relative contribution of local and macroscale constraints on cortical dynamics varies systematically across the cortical sheet, specifically highlighting the role of transmodal networks in inter-regional cortical coordination.
LB  - PUB:(DE-HGF)16
C6  - 41453863
UR  - <Go to ISI:>//WOS:001672450100005
DO  - DOI:10.1038/s41467-025-67740-2
UR  - https://juser.fz-juelich.de/record/1052262
ER  -