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@ARTICLE{Prott:1052301,
      author       = {Prott, Lea S. and Kaldenhoven, Vanessa and Hugger, Alfons
                      and Langner, Robert and Gierthmuehlen, Petra C. and
                      Gierthmuehlen, Mortimer},
      title        = {{T}ranscutaneous {A}uricular {V}agus {N}erve {S}timulation
                      for the {T}reatment of {M}yoarthropathic {S}ymptoms
                      {A}ssociated {W}ith {T}emporomandibular {D}isorders—{A}
                      {P}ilot {R}andomised {C}ontrolled {T}rial},
      journal      = {Journal of oral rehabilitation},
      volume       = {52},
      number       = {12},
      issn         = {0305-182X},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2026-00916},
      pages        = {2351 - 2360},
      year         = {2025},
      abstract     = {ABSTRACTBackground: Transcutaneous auricular vagus nerve
                      stimulation (taVNS) is a safe and feasible treatment for a
                      variety of acuteand chronic pain conditions. However, no
                      evidence about taVNS effectiveness in patients with chronic
                      pain associated with tem-poromandibular disorders (TMD) is
                      available.Objective: To evaluate the feasibility of and
                      compliance with taVNS in participants experiencing chronic
                      TMD pain and poten-tial effects on pain, psychological
                      well-being, muscle activity, and kinematics.Methods: Twenty
                      adults with chronic TMD pain were randomised to receive
                      taVNS (n = 10) or sham (n = 10). In the taVNSgroup,
                      stimulation was performed on the left tragus for 4 h daily
                      (25 Hz, pulse width 250 μs, 28 s on/32 s off). In the sham
                      group,an inactive non-functional sham electrode was used.
                      Patient-reported outcome measures (GCPS, PHQ-9, GAD-7,
                      PHQ-15, andOHIP- G14), muscle activity, and kinematics were
                      assessed at baseline, 4 weeks, and 8 weeks. Compliance was
                      assessed using asmartphone app, which recorded daily
                      stimulation time and intensity.Results: Recruitment and
                      retention rates were high $(100\%$ and $90\%,$
                      respectively), with $83\%$ adherence to the
                      intervention.Participants receiving taVNS showed a large
                      effect on oral health-related quality of life, and at least
                      a small but potentially impor-tant effect on pain intensity,
                      anxiety, depression, severity of somatic symptoms, muscle
                      activity, and kinematics. However, noneof these differences
                      were statistically significant. No serious adverse events
                      were identified.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {5251 - Multilevel Brain Organization and Variability
                      (POF4-525) / 5252 - Brain Dysfunction and Plasticity
                      (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5251 / G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      doi          = {10.1111/joor.70039},
      url          = {https://juser.fz-juelich.de/record/1052301},
}