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| Hauptseite > Publikationsdatenbank > COMPUTATIONAL MODELING OF NEURON-ASTROCYTE INTERACTIONS: TRIPARTITE CONNECTIVITY AND SYNAPTIC MODULATION |
| Hauptseite > Publikationsdatenbank > COMPUTATIONAL MODELING OF NEURON-ASTROCYTE INTERACTIONS: TRIPARTITE CONNECTIVITY AND SYNAPTIC MODULATION |
| Poster (After Call) | FZJ-2026-00948 |
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2025
Abstract: Astrocytes are integral components of neural circuits, actively participating in synaptic transmission and plasticity as well as in network function. This study advances computational modeling of neuron-astrocyte interactions, focusing on astrocyte-induced synaptic currents (SICs) and their modulatory influence on neuronal activity. We developed a biologically grounded model incorporating tripartite connectivity, where astrocytes selectively modulate the postsynaptic terminal of a neuron, extending beyond traditional binary synaptic connections. Implemented within the NEST simulation framework, our model integrates astrocytic calcium signaling and its downstream effects on postsynaptic neuronal excitability through SICs, offering a mechanistic representation of astrocyte-mediated modulation of synaptic activities.Simulations reveal that astrocytes modulate local neuronal network dynamics, with the extent of astrocyte-postsynaptic interactions significantly shaping overall network activity. By fine-tuning astrocytic parameters, the model exhibits transitions between asynchronous and synchronized neuronal states, demonstrating the role of astrocytes in coordinating neural oscillations and network states. Our results suggest that astrocytes influence neuronal excitability by regulating their glutamate release and modulating synaptic currents at the postsynaptic terminal.The NEST implementation of tripartite connectivity provides a generic framework for combining arbitrary rule-based primary and third-factor connectivity. Using our model, we show that our approach scales well up to at least 1 million cells. Our framework thus facilitates realistic and reproducible modeling of neuron-glia interactions, providing insights into the role of astrocytes in both physiological and pathological conditions. By offering an accessible and computationally efficient tool for simulating neuron-astrocyte dynamics, this study supports further investigation into glial contributions to neural function and disease.
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