TY  - JOUR
AU  - Gierse, Martin
AU  - Dagys, Laurynas
AU  - Keim, Michael
AU  - Lucas, Sebastian
AU  - Josten, Felix
AU  - Plenio, Martin B.
AU  - Schwartz, Ilai
AU  - Knecht, Stephan
AU  - Eills, James
TI  - Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion
JO  - Angewandte Chemie / International edition
VL  - 63
IS  - 34
SN  - 1433-7851
CY  - Weinheim
PB  - Wiley-VCH
M1  - FZJ-2026-01305
SP  - e202319341
PY  - 2024
AB  - Parahydrogen-induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with polarization levels of >10 % in the solution-state, but is strongly limited in generality since it requires chemical reactions/ interactions with H2. Here we report a new method to widen the scope of PHIP hyperpolarization: a source molecule is produced via PHIP with high 13C polarization, and precipitated out of solution together with a target species. Spin diffusion within the solid carries the polarization onto 13C spins of the target, which can then be dissolved for solution-state applications. We name this method PHIP-SSD (PHIP with solid-state spin diffusion) and demonstrate it using PHIP-polarized [1-13C]-fumarate as the source molecule, to polarize different 13C-labelled target molecules. 13C polarizations of between 0.01 and 3 % were measured on [1-13C]-benzoic acid, depending on the molar ratio of fumarate:benzoate in the solid state. We also show that PHIP-SSD does not require specific co-crystallization conditions by grinding dry powders of target molecules together with solid fumarate crystals, and obtain 13C signal enhancements of between 100 and 200 on [13C,15N2]-urea, [1-13C]-pyruvate, and [1-13C]-benzoic acid. This approach appears to be a promising new strategy for facile hyperpolarization based on PHIP.
LB  - PUB:(DE-HGF)16
DO  - DOI:10.1002/anie.202319341
UR  - https://juser.fz-juelich.de/record/1052955
ER  -