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| 001 | 1052955 | ||
| 005 | 20260128204148.0 | ||
| 024 | 7 | _ | |a 10.1002/anie.202319341 |2 doi |
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| 100 | 1 | _ | |a Gierse, Martin |0 0000-0002-8187-5903 |b 0 |
| 245 | _ | _ | |a Hyperpolarizing Small Molecules using Parahydrogen and Solid‐State Spin Diffusion |
| 260 | _ | _ | |a Weinheim |c 2024 |b Wiley-VCH |
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| 520 | _ | _ | |a Parahydrogen-induced polarization (PHIP) is an inexpensive way to produce hyperpolarized molecules with polarization levels of >10 % in the solution-state, but is strongly limited in generality since it requires chemical reactions/ interactions with H2. Here we report a new method to widen the scope of PHIP hyperpolarization: a source molecule is produced via PHIP with high 13C polarization, and precipitated out of solution together with a target species. Spin diffusion within the solid carries the polarization onto 13C spins of the target, which can then be dissolved for solution-state applications. We name this method PHIP-SSD (PHIP with solid-state spin diffusion) and demonstrate it using PHIP-polarized [1-13C]-fumarate as the source molecule, to polarize different 13C-labelled target molecules. 13C polarizations of between 0.01 and 3 % were measured on [1-13C]-benzoic acid, depending on the molar ratio of fumarate:benzoate in the solid state. We also show that PHIP-SSD does not require specific co-crystallization conditions by grinding dry powders of target molecules together with solid fumarate crystals, and obtain 13C signal enhancements of between 100 and 200 on [13C,15N2]-urea, [1-13C]-pyruvate, and [1-13C]-benzoic acid. This approach appears to be a promising new strategy for facile hyperpolarization based on PHIP. |
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| 700 | 1 | _ | |a Dagys, Laurynas |0 0000-0003-4935-6115 |b 1 |
| 700 | 1 | _ | |a Keim, Michael |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Lucas, Sebastian |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Josten, Felix |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Plenio, Martin B. |0 0000-0003-4238-8843 |b 5 |
| 700 | 1 | _ | |a Schwartz, Ilai |0 P:(DE-HGF)0 |b 6 |e Corresponding author |
| 700 | 1 | _ | |a Knecht, Stephan |0 0000-0002-8487-4324 |b 7 |e Corresponding author |
| 700 | 1 | _ | |a Eills, James |0 P:(DE-Juel1)204392 |b 8 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1002/anie.202319341 |g Vol. 63, no. 34, p. e202319341 |0 PERI:(DE-600)2011836-3 |n 34 |p e202319341 |t Angewandte Chemie / International edition |v 63 |y 2024 |x 1433-7851 |
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