TY  - JOUR
AU  - Röttgen, Sinah
AU  - Sommerauer, Michael
AU  - Yan, Shijun
AU  - Hungerland, Carolin
AU  - Fink, Gereon Rudolf
AU  - Ophey, Anja
AU  - Barbe, Michael T.
AU  - Müller, Laura
AU  - Tamgüney, Gültekin
AU  - Tofaris, George K.
TI  - Compartment-specific correlation of pathological α-synuclein in prodromal Parkinson's disease
JO  - Parkinsonism & related disorders
VL  - 144
SN  - 1353-8020
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2026-01496
SP  - 108178 -
PY  - 2026
N1  - Funding Else Kroner-Fresenius-Stiftung (grant number 2019_EKES.02); Koln Fortune Program, Faculty of Medicine, University of Cologne; Ilselore-Luckow-Stiftung.
AB  - ntroductionNeuronal α-synuclein dyshomeostasis and aggregation are essential features of early Parkinson's disease, as seen in isolated REM sleep behavior disorder (iRBD). The link between these pathologies across body compartments remains unclear. Our aim was to assess correlations between α-synuclein aggregates in stool and urine with α-synuclein content in neuronally derived L1CAM extracellular vesicles (L1EVs) from serum in iRBD.MethodsWe conducted a cross-sectional study, analyzing concurrent biobank samples from 46 individuals with iRBD to quantify α-synuclein aggregates in stool and urine with surface-based fluorescence intensity distribution analysis (sFIDA) and α-synuclein content in L1EVs using electrochemiluminescence.ResultsCorrected for age and sex, α-synuclein concentrations in L1EVs significantly correlated with stool aggregate concentration. No significant correlation was observed between α-synuclein concentration in L1EVs and urine, nor between urine and stool aggregates.ConclusionThe correlation of serum and stool α-synuclein suggests shared or linked pathology across these compartments, whereas the urinary compartment may be pathophysiologically distinct in prodromal Parkinson's Disease.
LB  - PUB:(DE-HGF)16
C6  - 41512492
UR  - <Go to ISI:>//WOS:001665926300001
DO  - DOI:10.1016/j.parkreldis.2026.108178
UR  - https://juser.fz-juelich.de/record/1053164
ER  -