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@ARTICLE{Rttgen:1053164,
      author       = {Röttgen, Sinah and Sommerauer, Michael and Yan, Shijun and
                      Hungerland, Carolin and Fink, Gereon Rudolf and Ophey, Anja
                      and Barbe, Michael T. and Müller, Laura and Tamgüney,
                      Gültekin and Tofaris, George K.},
      title        = {{C}ompartment-specific correlation of pathological
                      α-synuclein in prodromal {P}arkinson's disease},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {144},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2026-01496},
      pages        = {108178 -},
      year         = {2026},
      note         = {Funding Else Kroner-Fresenius-Stiftung (grant number
                      $2019_EKES.02);$ Koln Fortune Program, Faculty of Medicine,
                      University of Cologne; Ilselore-Luckow-Stiftung.},
      abstract     = {ntroductionNeuronal α-synuclein dyshomeostasis and
                      aggregation are essential features of early Parkinson's
                      disease, as seen in isolated REM sleep behavior disorder
                      (iRBD). The link between these pathologies across body
                      compartments remains unclear. Our aim was to assess
                      correlations between α-synuclein aggregates in stool and
                      urine with α-synuclein content in neuronally derived L1CAM
                      extracellular vesicles (L1EVs) from serum in iRBD.MethodsWe
                      conducted a cross-sectional study, analyzing concurrent
                      biobank samples from 46 individuals with iRBD to quantify
                      α-synuclein aggregates in stool and urine with
                      surface-based fluorescence intensity distribution analysis
                      (sFIDA) and α-synuclein content in L1EVs using
                      electrochemiluminescence.ResultsCorrected for age and sex,
                      α-synuclein concentrations in L1EVs significantly
                      correlated with stool aggregate concentration. No
                      significant correlation was observed between α-synuclein
                      concentration in L1EVs and urine, nor between urine and
                      stool aggregates.ConclusionThe correlation of serum and
                      stool α-synuclein suggests shared or linked pathology
                      across these compartments, whereas the urinary compartment
                      may be pathophysiologically distinct in prodromal
                      Parkinson's Disease.},
      cin          = {INM-3 / IBI-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)IBI-7-20200312},
      pnm          = {5252 - Brain Dysfunction and Plasticity (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5252},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {41512492},
      UT           = {WOS:001665926300001},
      doi          = {10.1016/j.parkreldis.2026.108178},
      url          = {https://juser.fz-juelich.de/record/1053164},
}