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@INPROCEEDINGS{Werner:1053911,
      author       = {Werner, Jan-Michael and Müller, Katharina J and Mair,
                      Maximilian J and Peplinski, Jana-Marie and Kraft, Manuel and
                      Hilgers, Julia and Ciantar, Keith G and Fink, Gereon R and
                      Goldbrunner, Roland and Shah, Nadim J and Mottaghy, Felix M
                      and Langen, Karl-Josef and Lohmann, Philipp and Preusser,
                      Matthias and Albert, Nathalie L and Galldiks, Norbert},
      title        = {{IMG}-88. {P}rognostic relevance of preoperative {FET}
                      {PET} in patients with newly diagnosed glioblastoma},
      issn         = {1523-5866},
      reportid     = {FZJ-2026-01609},
      year         = {2025},
      abstract     = {AbstractBACKGROUNDThe present study investigated the
                      prognostic relevance of O-(2-[18F]fluoroethyl)-L-tyrosine
                      (FET) PET parameters in newly diagnosed IDH-wildtype
                      glioblastoma.METHODSFifty patients with newly diagnosed and
                      histomolecularly characterized glioblastoma according to the
                      WHO 2021 classification who had undergone FET PET imaging
                      prior to diagnostic biopsy or surgery and subsequent
                      postoperative radiotherapy with concomitant and adjuvant
                      temozolomide (n=36) or temozolomide plus lomustine (n=14)
                      were retrospectively analyzed. The nnUNet-based
                      $JuST_BrainPET$ tool was used for segmentation of the FET
                      PET tumor volume based on a tumor-to-brain ratio (TBR) of
                      ≥1.6. All segmentations were visually checked.
                      Quantitative PET parameters, i.e., maximum and mean TBR
                      values, and metabolic tumor volumes (MTV), were correlated
                      with overall survival (OS) using Cox regression models.
                      Additional clinical parameters included age (range, 26-82
                      years), MGMT promoter methylation status (methylated in
                      $58\%$ of patients), RANO resection class (range, 2-4),
                      treatment regimen, and postoperative Karnofsky Performance
                      Status (range, $60-100\%)$ and NANO score (range, 0-7
                      points),RESULTSIn univariate Cox regression, preoperative
                      MTV (hazard ratio [HR], 1.10; $95\%$ CI, 1.04-1.17; p=0.002)
                      and unmethylated MGMT promoter (HR, 2.82; $95\%$ CI,
                      1.22-6.70; p=0.016) were the only parameters significantly
                      associated with shorter OS. In multivariate analysis, MTV
                      remained prognostic (p=0.003), as well as MGMT promoter
                      methylation status (p=0.031). Model comparison using
                      Akaike’s Information Criterion favored MTV over MGMT
                      promoter methylation as the better overall prognostic
                      fit.CONCLUSIONThese data support the integration of the FET
                      PET tumor volume as prognostic biomarker in glioblastoma
                      risk stratification. Further studies with larger datasets
                      are needed to substantiate our findings.Topic:
                      positron-emission tomography biopsy glioblastoma immunologic
                      adjuvants pharmaceutical adjuvants foreign medical graduates
                      karnofsky performance status lomustine methylation
                      o(6)-methylguanine-dna methyltransferase preoperative care
                      surgical procedures, operative world health organization
                      brain diagnosis neoplasms patient prognosis surgery
                      specialty tyrosine temozolomide prognostic marker
                      postoperative radiotherapy stratification cox proportional
                      hazards models tumor volume datasets},
      month         = {Nov},
      date          = {2025-11-20},
      organization  = {7th Quadrennial Meeting of the World
                       Federation of Neuro-Oncology Societies,
                       Honolulu (USA), 20 Nov 2025 - 23 Nov
                       2025},
      cin          = {INM-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406},
      pnm          = {5253 - Neuroimaging (POF4-525)},
      pid          = {G:(DE-HGF)POF4-5253},
      typ          = {PUB:(DE-HGF)1},
      doi          = {10.1093/neuonc/noaf201.1167},
      url          = {https://juser.fz-juelich.de/record/1053911},
}