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| Hauptseite > Publikationsdatenbank > Disentangling the influences of pre- and postnatal periods on human cortical microstructure > print |
| Hauptseite > Publikationsdatenbank > Disentangling the influences of pre- and postnatal periods on human cortical microstructure > print |
| 001 | 1053974 | ||
| 005 | 20260203091017.0 | ||
| 024 | 7 | _ | |a 10.1101/2025.08.12.669812 |2 doi |
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| 100 | 1 | _ | |a Tsigaras, Thanos |0 P:(DE-Juel1)195707 |b 0 |e First author |u fzj |
| 245 | _ | _ | |a Disentangling the influences of pre- and postnatal periods on human cortical microstructure |
| 260 | _ | _ | |a Cold Spring Harbor |c 2025 |b Cold Spring Harbor Laboratory, NY |
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| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 520 | _ | _ | |a During late gestation and early postnatal development a combination of intrinsic and extrinsic factors drive the maturation of the human cortex. This process is regionally heterogeneous, with cortical areas developing at different paces and trajectories. Leveraging submillimetre T1-weighted/T2w-weighted (T1w/T2w) magnetic resonance imaging (MRI) from pre- and full-term neonates (n = 599, 0-7 weeks), we sampled intracortical microstructure profiles across the cortex and characterised the profiles’ shapes according to their central moments. We found that gestational age at birth dominated the effects on early cortical development, with significant, global increases in microstructural density, increasing intracortical homogeneity and a bimodal change of the microstructural balance between superficial and deeper cortical layers. On the other hand, weeks since birth (i.e. postnatal age) exhibited different effects on microstructure, with density increasing at a slower pace, increasing intracortical heterogeneity, and intracortical balance only shifting towards deeper layers in posterior temporal, occipital, medial parietal areas and some prefrontal areas. These effects align with low spatial-frequency geometric eigenmodes of the human cortex, specifically the anterior-posterior, superior-inferior and central-polar axes. Our findings demonstrate that separating prenatal from postnatal influences, and analysing intracortical profiles rather than macroscale features, provides finer-grained insights into how human cortical microstructure changes during perinatal development and lays the groundwork for investigating the biological underpinnings that govern normative cortical maturation. |
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| 700 | 1 | _ | |a Paquola, Casey |0 P:(DE-Juel1)187055 |b 4 |e Corresponding author |u fzj |
| 773 | _ | _ | |a 10.1101/2025.08.12.669812 |0 PERI:(DE-600)2766415-6 |t bioRxiv beta |y 2025 |
| 856 | 4 | _ | |u https://www.biorxiv.org/content/10.1101/2025.08.12.669812v1.full |
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