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@ARTICLE{Schfer:10585,
      author       = {Schäfer, C. and Born, S. and Möhl, C. and Houben, S. and
                      Kirchgeßner, N. and Merkel, R. and Hoffmann, B.},
      title        = {{T}he key feature for early migratory processes:
                      {D}ependence of adhesion actin bundles, force generation and
                      transmission of filopodia},
      journal      = {Cell adhesion $\&$ migration},
      volume       = {4},
      issn         = {1933-6918},
      address      = {Austin, Tex.},
      publisher    = {Landes Bioscience},
      reportid     = {PreJuSER-10585},
      pages        = {215 - 225},
      year         = {2010},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Migration of cells is one of the most essential
                      prerequisites to form higher organisms and depends on a
                      strongly coordinated sequence of processes. Early migratory
                      events include substrate sensing, adhesion formation, actin
                      bundle assembly and force generation. While substrate
                      sensing was ascribed to filopodia, all other processes were
                      believed to depend mainly on lamellipodia of migrating
                      cells. In this work we show for motile keratinocytes that
                      all processes from substrate sensing to force generation
                      strongly depend on filopodial focal complexes as well as on
                      filopodial actin bundles. In a coordinated step by step
                      process, filopodial focal complexes have to be tightly
                      adhered to the substrate and to filopodial actin bundles to
                      enlarge upon lamellipodial contact forming classical focal
                      adhesions. Lamellipodial actin filaments attached to those
                      focal adhesions originate from filopodia. Upon cell
                      progression, the incorporation of filopodial actin bundles
                      into the lamellipodium goes along with a complete change in
                      actin cross-linker composition from filopodial fascin to
                      lamellipodial alpha-actinin. alpha-Actinin in turn is
                      replaced by myosin II and becomes incorporated directly
                      behind the leading edge. Myosin II activity makes this class
                      of actin bundles with their attached FAs the major source of
                      force generation and transmission at the cell front.
                      Furthermore, connection of FAs to force generating actin
                      bundles leads to their stabilization and further
                      enlargement. Consequently, adhesion sites formed
                      independently of filopodia are not connected to detectable
                      actin bundles, transmit weak forces to the substrate and
                      disassemble within a few minutes without having been
                      increased in size.},
      keywords     = {J (WoSType)},
      cin          = {IBN-4},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB802},
      pnm          = {BioSoft: Makromolekulare Systeme und biologische
                      Informationsverarbeitung},
      pid          = {G:(DE-Juel1)FUEK505},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000208234700014},
      doi          = {10.4161/cam.4.2.10745},
      url          = {https://juser.fz-juelich.de/record/10585},
}